10444-38-9

Basic information

• Product Name: 4-Cyanobutyric acid ethyl ester
• Synonyms: 4-Cyanobutanoic acid ethyl ester;4-Cyanobutyric acid ethyl ester
• CAS NO: 10444-38-9
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Mol File: 10444-38-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 242-247 °C
• Appearance: /
• Density: 1.001±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Cyanobutyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyanobutyric acid ethyl ester(10444-38-9)
• EPA Substance Registry System: 4-Cyanobutyric acid ethyl ester(10444-38-9)

Safety Data

• Hazardous Substances Data: 10444-38-9(Hazardous Substances Data)

Usage

General Description

4-Cyanobutyric acid ethyl ester is a chemical compound with the molecular formula C7H11NO2. It is also known as ethyl 4-cyanobutyrate and is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4-Cyanobutyric acid ethyl ester is a colorless liquid with a fruity odor and is considered to be a moderately hazardous substance. It is important to handle 4-Cyanobutyric acid ethyl ester with caution and to follow proper safety protocols when working with this chemical.

Upstream product

• 623-72-3 ethyl 3-hydroxypropanoate 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 17216-62-5 diethyl 2-(2-cyanoethyl)malonate 
• 42586-31-2 ω-Oximino-valeriansaeure-aethylester 
• 34405-09-9 ethyl 2,2,4-trichloro-4-cyanobutanoate 
• 151-50-8 potassium cyanide 
• 7425-53-8 ethyl 4-iodobutyrate 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 950609-79-7 5-acetyl-3-(3-ethoxycarbonylpropyl)-2-isoxazoline 
• 1094201-37-2 4-cyano-2-(ethoxycarbonyl)butanoic acid 
• 773837-37-9 sodium cyanide 
• 64-17-5 ethanol 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 675-20-7 piperidin-2-one 
• 75866-46-5 ethyl 5-(2-oxopiperidin-1-yl)pentanoate 
• 41126-15-2 methyl 4-cyanobutanoate 
• 1427203-27-7 N-(benzyloxy)-4-cyano-N-methylbutanamide 
• 1427203-30-2 N-(benzyloxy)-N-methyl-4-(1H-tetrazol-5-yl)butanamide 
• 1427203-24-4 N-(benzyloxy)-4-cyanobutanamide 
• 7056-90-8 (Z)-Hexadec-5-enoic Acid 
• 22668-36-6 ethyl 5-oxopentanoate 
• 70432-50-7 ethyl 5-oxoheptanoate 
• 546114-04-9 4-azaspiro[2.5]octan-5-one 

Relevant articles and documents

Tin-free radical cyanation of alkyl iodides and alkyl phenyl tellurides

As a result of much faster phenyl telluride group transfer relative to the corresponding iodine atom transfer, tin-free radical cyanation of alkyl phenyl tellurides has been achieved with p-toluenesufonyl cyanide and methyl allyl sulfone in the presence of V-40 as initiator.

NOVEL GLYCINE TRANSPORT INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to novel glycine transport inhibitor compounds and their use for treating pain.

MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS

The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

Template Catalysis by Metal-Ligand Cooperation. C-C Bond Formation via Conjugate Addition of Non-activated Nitriles under Mild, Base-free Conditions Catalyzed by a Manganese Pincer Complex

The first example of a catalytic Michael addition reaction of non-activated aliphatic nitriles to α,β-unsaturated carbonyl compounds under mild, neutral conditions is reported. A new de-aromatized pyridine-based PNP pincer complex of the Earth-abundant, first-row transition metal manganese serves as the catalyst. The reaction tolerates a variety of nitriles and Michael acceptors with different steric features and acceptor strengths. Mechanistic investigations including temperature-dependent NMR spectroscopy and DFT calculations reveal that the cooperative activation of alkyl nitriles, which leads to the generation of metalated nitrile nucleophile species (α-cyano carbanion analogues), is a key step of the mechanism. The metal center is not directly involved in the catalytic bond formation but rather serves, cooperatively with the ligand, as a template for the substrate activation. This approach of "template catalysis" expands the scope of potential donors for conjugate addition reactions.