1050446-94-0

Basic information

• Product Name: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: D-1-N-CBZ-NIPECOTAMIDE;(R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;(R)-1-Cbz-3-piperidinecarboxaMide
• CAS NO: 1050446-94-0
• Molecular Formula: C14H18N2O3
• Molecular Weight: 262.30432
• Mol File: 1050446-94-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(1050446-94-0)
• EPA Substance Registry System: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(1050446-94-0)

Safety Data

• Hazardous Substances Data: 1050446-94-0(Hazardous Substances Data)

Usage

General Description

"(R)-3-Carbamoyl-piperidine-1-carboxylic acid benzyl ester" is a chemical compound with a molecular formula C15H19N3O4. It is an ester derived from (R)-3-Carbamoyl-piperidine-1-carboxylic acid and benzyl alcohol. (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER has potential applications in pharmaceutical and medicinal chemistry due to its structural features and potential biological activities. It could be used as a building block for the synthesis of various drug molecules or as a precursor for the development of new therapeutic agents. Additionally, its unique chemical structure and properties may also make it suitable for use in chemical research and development.

Upstream product

• 78190-11-1 1-benzyloxycarbonylpiperidine-3-carboxylic acid 
• 1026661-43-7 (S)-piperidine-3-carboxylic acid amide hydrochloride 
• 501-53-1 benzyl chloroformate 
• 160706-62-7 (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 

Downstream Products

• 1044560-96-4 (R)-benzyl 3-aminopiperidine-1-carboxylate 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 

Relevant articles and documents

(R)- 3 - Boc - amino piperidine preparation method

The invention discloses a preparation method of (R)-3-Boc-aminopiperidine and relates to the technical field of preparation of piperidine heterocyclic compounds. The preparation method includes following steps: (1) with N-Cbz-3-piperidinecarboxylic acid as a raw material, performing chiral resolution with R-phenylethylamine to obtain a compound I; (2) performing an acid-amide condensation reaction to the compound I and ammonia gas to obtain a compound II; (3) performing a Hofmann degradation reaction to the compound II to obtain a compound III; (4) performing protection to the compound III with di-tert-butyl dicarbonate to obtain a compound IV; and (5) performing a hydrogenation and Cbz-removal reaction to the compound IV to prepare the (R)-3-Boc-aminopiperidine. The method is mild in reaction conditions, is safe and reliable, is excellent in process stability, is low in energy consumption, is high in yield, is green and environment-protective and is suitable for industrial production.

OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I), wherein P3A, W, B, Q, Rl and R2 are defined as in formula (I); invention compounds are positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the tr