1050446-94-0

Basic information

• Product Name: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: D-1-N-CBZ-NIPECOTAMIDE;(R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;(R)-1-Cbz-3-piperidinecarboxaMide
• CAS NO: 1050446-94-0
• Molecular Formula: C14H18N2O3
• Molecular Weight: 262.30432
• Mol File: 1050446-94-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(1050446-94-0)
• EPA Substance Registry System: (R)-3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(1050446-94-0)

Safety Data

• Hazardous Substances Data: 1050446-94-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
(R)-3-Carbamoyl-piperidine-1-carboxylic acid benzyl ester is used as a building block for the synthesis of various drug molecules. Its structural features and potential biological activities contribute to the development of new therapeutic agents.
Used in Chemical Research and Development:
Due to its unique chemical structure and properties, (R)-3-Carbamoyl-piperidine-1-carboxylic acid benzyl ester is also suitable for use in chemical research and development, where it can be further explored for its potential applications and properties.

Upstream product

• 160706-62-7 (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 
• 78190-11-1 1-benzyloxycarbonylpiperidine-3-carboxylic acid 
• 1026661-43-7 (S)-piperidine-3-carboxylic acid amide hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1044560-96-4 (R)-benzyl 3-aminopiperidine-1-carboxylate 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 

Relevant articles and documents

(R)- 3 - Boc - amino piperidine preparation method

The invention discloses a preparation method of (R)-3-Boc-aminopiperidine and relates to the technical field of preparation of piperidine heterocyclic compounds. The preparation method includes following steps: (1) with N-Cbz-3-piperidinecarboxylic acid as a raw material, performing chiral resolution with R-phenylethylamine to obtain a compound I; (2) performing an acid-amide condensation reaction to the compound I and ammonia gas to obtain a compound II; (3) performing a Hofmann degradation reaction to the compound II to obtain a compound III; (4) performing protection to the compound III with di-tert-butyl dicarbonate to obtain a compound IV; and (5) performing a hydrogenation and Cbz-removal reaction to the compound IV to prepare the (R)-3-Boc-aminopiperidine. The method is mild in reaction conditions, is safe and reliable, is excellent in process stability, is low in energy consumption, is high in yield, is green and environment-protective and is suitable for industrial production.

CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (I)

OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I), wherein P3A, W, B, Q, Rl and R2 are defined as in formula (I); invention compounds are positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the tr