78190-11-1

Basic information

• Product Name: 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid
• Synonyms: 1,3-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester;1-Cbz-3-piperidinecarboxylic Acid;3-R-(-)-CBZ-piperidinecarboxylic acid;1-Carbobenzoxy-3-piperidinecarboxylic Acid;1-Cbz-3-piperidine-3-carboxylic acid;1-CBZ-PIPERIDINE-3-CARBOXYLIC ACID;1-[(BENZYLOXY)CARBONYL]-3-PIPERIDINECARBOXYLIC ACID;1-[(BENZYLOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID
• CAS NO: 78190-11-1
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.29
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Piperidine
• Mol File: 78190-11-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 90-94 °C
• Boiling Point: 443.9 °C at 760 mmHg
• Flash Point: 222.3 °C
• Appearance: /
• Density: 1.265 g/cm³
• Vapor Pressure: 1.16E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 4.48±0.20(Predicted)
• CAS DataBase Reference: 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid(78190-11-1)
• EPA Substance Registry System: 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid(78190-11-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-37/39-39
• Hazardous Substances Data: 78190-11-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C14H17NO4/c16-13(17)12-7-4-8-15(9-12)14(18)19-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10H2,(H,16,17)/p-1/t12-/m0/s1

Upstream product

• 501-53-1 benzyl chloroformate 
• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 498-95-3 nipecotic acid 

Downstream Products

• 301180-04-1 tert-butyl N-benzyloxycarbonyl nipecotate 
• 310454-53-6 3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 
• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 1044560-96-4 (R)-benzyl 3-aminopiperidine-1-carboxylate 
• 1050446-94-0 C₁₄H₁₈N₂O₃ 
• 160706-62-7 (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 
• 569348-14-7 benzyl 3-carbamoylpiperidine-1-carboxylate 

Relevant articles and documents

NEW LIPOGENESIS INHIBITOR COMPOUNDS

The present invention relates to Formula (I), wherein—if X=NH, each of R1, R2, R3, R4 represents a hydrogen atom; if X=N, the core is aromatic, and R2, R3 and R4 represent hydrogen atoms, and R1=H, halogen, aryl, heteroaryl, alkenyl or acetylenyl; or R1, R2, R3, R4 are defined such that R1 or R2 or R3 or R4 represents a methyl group, and the three other radicals represent a hydrogen atom.

BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Novel piperidyl derivatives of quinazoline and isoquinoline

The invention pertains to new piperidyl-substituted quinazoline and isoquinoline derivatives that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.