104464-04-2

Upstream product

• 34857-28-8 (S)-2-methyl-1-phenylpropan-1-ol 
• 99268-87-8 3-(p-toluenesulfonyl)-2-pyrone 
• 106968-19-8 (S)-2 

Downstream Products

• 104487-42-5 (4R,6S)-4-Hydroxy-6-((S)-2-methyl-1-phenyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 104464-05-3 (1R,4S,6S)-4-Hydroxy-6-((S)-2-methyl-1-phenyl-propoxy)-1-(toluene-4-sulfonyl)-cyclohex-2-enecarboxylic acid methyl ester 
• 104528-69-0 methyl 3,4,5-tri-O-acetyl-4-epi-shikimate 
• 104464-22-4 (3R,4S,6S)-3,4-Diacetoxy-6-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 104464-08-6 (3R,4S,6S)-3,4-Dihydroxy-6-((S)-2-methyl-1-phenyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 104464-09-7 (3R,4S,6S)-3,4-Diacetoxy-6-((S)-2-methyl-1-phenyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 127492-00-6 (4R,6S)-4,6-Dihydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 127492-02-8 (4R-trans)-4,6-Bis(tert-butyldimethylsiloxy)-1-cyclohexenemethanol 
• 127492-01-7 chiron 
• 127491-99-0 (1RS,3S,5R)-3,5-bis(t-butyldimethylsiloxy)-1-carboethoxymethyl-2-methylenecyclohexane 
• 161167-55-1 [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Asymmetric total synthesis of an a-ring precursor to hormonally active 1α,25-dihydroxyvitamin D3

A new sulfinyl orthoester has been designed and used effectively in one-flask syntheses of dienoate esters from allylic alcohols; this new method as well as a highly stereocontrolled [2 + 4]-cycloaddition are applied to synthesis of 1α,25-dihydroxyvitamin D3.

ASYMMETRIC DIELS-ALDER CYCLOADDITIONS USING CHIRAL ALKYL VINYL ETHERS AND A DIENYL SULFONE

Chiral alkyl vinyl ethers 2b-2j underwent mild, inverse electron demand, Diels-Alder cycloadditions with 3-arenesulfonyl-2-pyrone 1 to form bridged bicyclic lactone adducts 3b-3j in excellent yields and with diastereoselectivities of up to 90percent.