1044740-40-0

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 176240-12-3 (2S)-1-benzylpirrolidine-2-carbaldehyde 
• 100-39-0 benzyl bromide 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 628292-12-6 (2S)-1-triphenylmethyl-2-pyrrolidinemethanal 
• 147-85-3 L-proline 
• 179918-60-6 (2S)-1-triphenylmethyl-2-pyrrolidinemethanol 
• 13515-74-7 (2S)-1-triphenylmethyl-2-pyrrolidinecarboxylic acid 

Relevant academic research and scientific papers

Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3-Substituted 2-(Trifluoromethyl)piperidines

3-Substituted 2-(trifluoromethyl)piperidines B were synthesized by ring expansion of (trifluoromethyl)prolinols A, which were obtained from l-proline via an aziridinium intermediate C. The ring opening of the (trifluoromethyl)aziridinium intermediate by different nucleophiles is regio- and diastereoselective.

Synthesis and utilization of trifluoromethylated amino alcohol ligands for the enantioselective Reformatsky reaction and addition of diethylzinc to N-(diphenylphosphinoyl)imine

A series of trifluoromethylated amino alcohol ligands, which had been designed and conveniently prepared, were successfully applied in the enantioselective Reformatsky reaction and addition of diethylzinc to N-(diphenylphosphinoyl)imine, respectively. The influence of the substituents on C-3 position and the amino moiety on the enantioselectivity has been carefully investigated. In the best cases, ligand 1b exhibited good selectivity for the enantioselective Reformatsky reaction in 86% ee and ligand 12d provided excellent enantioselectivity in the addition of diethylzinc to N-(diphenylphosphinoyl)imine with 95% ee.