104494-93-1Relevant articles and documents
Polymer-resin hybrid capture-release strategy for rapid oligosaccharide construction
Hanashima, Shinya,Manabe, Shino,Ito, Yukishige
, p. 979 - 982 (2007/10/03)
The polymer-resin hybrid type capture-release purification strategy for oligosaccharide synthesis was renewed as more rapid and straightforward manner. The substrate for N-acetylglucosaminyltransferase V trisaccharide was synthesized rapidly on PEG (poly (ethylene glycol) methyl ether) and purified by use of the strategy.
NEPHROTROPIC DRUGS
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, (2008/06/13)
Disclosed are a drug having renal selectivity and a drug carrier for specifically transporting a drug supported thereon to a kidney. A segment structure specifically recognizable in the kidney is utilized. More specifically, since a segment structure repr
Synthesis and antidiuretic activities of novel glycoconjugates of arginine-vasopressin
Susaki, Hiroshi,Suzuki, Kokichi,Ikeda, Masahiro,Yamada, Harutami,Watanabe, Hiroshi K.
, p. 1530 - 1537 (2007/10/03)
Arginine-vasopressin (AVP) was acylated with various acyl azides (2a-j) in pH 9.1 buffer to give AVP derivatives (11a-j) modified at the tyrosine side chain with a carbohydrate via a spacer arm. Glycoconjugates of AVP modified at the N-terminal amide (12a
Syntheses of spacer-armed carbohydrate model compounds
Kerekgyarto, Janos,Nagy, Zoltan,Szurmai, Zoltan
, p. 107 - 115 (2007/10/03)
Commercially available chemicals, such as diethylene glycol, 1,9-nonanediol, 9-decen-1-ol, 1,2,6-hexanetriol, and p-nitrophenol were used to prepare spacer-armed carbohydrate derivatives. Glycosides of D-glucose, N-acetyl-D-glucosamine and 3-O-methyl-D-glucose have been synthesized, carrying reactive groups at the end of the spacer-arms. These glycosides are capable of forming neoglycoproteins. When bromo sugars were reacted with highly apolar aglycones in the presence of mercuric cyanide or mercuric bromide, a considerable amount of '2-OH-compounds' (such as 9-hydroxynonyl 3,4,6-tri-O-acetyl-β-D-glucopyranoside) were formed. Some spacer-armed derivatives (such as 9,10-epoxydecyl β-D-glucopyranoside) are theoretically a mixture of diastereomers, but this fact does not mirror in the 1H and 13C NMR spectra.
Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists
Roy, Rene,Park, William K. C.,Srivastava, Om P.,Foxall, Carrol
, p. 1399 - 1402 (2007/10/03)
Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water- soluble copolyacrylamide showed inhibition of binding of both L- and E- selectins in the μMolar range.
SYNTHESIS OF IMMUNOSUPPRESIVE NEOGLYCOPROTEINS: BOVINE SERUM ALBUMIN COUPLED WITH 8-(HYDRAZINOCARBONYL)OCTYL 4- OR 6-O-&α-D-MANNOPYRANOSYL-&α-D-MANNOPYRANOSIDE
Wada, Kaoru,Chiba, Taku,Takei, Yutaka,Ishihara, Hideko,Hayashi, Hidetoshi,Onozaki, Kikuo
, p. 941 - 966 (2007/10/02)
Recombinant cytokines generated by bacteria, especially E.coli, are nonglycosylated.To investigate the effects of carbohydrates on their activities, we attempted to develop new cytokines by introduction of carbohydrates.As a model we synthesized neoglycop
Synthesis of phosphorylated trimannosides corresponding to end groups of the high-mannose chains of lysosomal enzymes.
Srivastava,Hindsgaul
, p. 195 - 210 (2007/10/02)
Glycosylation of suitably protected 8-methoxycarbonyloctyl alpha-D-manno-pyranosides with 2-O-acetyl-3,4,6-tri-O-benzyl-alpha-D-mannopyranosyl chloride provided alpha-D-Manp-(1----2)-alpha-D-Man, alpha-D-Manp-(1----3)-alpha-D-Man and alpha-D-Manp-(1----6)