10453-25-5

Usage

Uses

Used in Dietary Supplements:
(22E)-3β-Methoxystigmasta-5,22-diene is used as a dietary supplement for its potential health-promoting properties, such as lowering cholesterol levels and supporting cardiovascular health.
Used in Functional Foods:
(22E)-3β-Methoxystigmasta-5,22-diene is added to functional foods to provide consumers with potential therapeutic effects, including its anti-inflammatory and anti-cancer properties.
Used in Pharmaceutical Industry:
(22E)-3β-Methoxystigmasta-5,22-diene is used as a pharmaceutical candidate for its potential health benefits, including its ability to lower cholesterol and support cardiovascular health, as well as its anti-inflammatory and anti-cancer properties.
Used in Nutraceutical Industry:
(22E)-3β-Methoxystigmasta-5,22-diene is used in the nutraceutical industry for its potential health-promoting properties, such as lowering cholesterol levels and supporting cardiovascular health, as well as its anti-inflammatory and anti-cancer properties.

Upstream product

• 67-56-1 methanol 
• 53139-42-7 stigmasteryl tosylate 
• 127-09-3 sodium acetate 
• 53603-94-4 6β-methoxy-3α,5α-cyclo-stigmast-22t-ene 
• 83-48-7 Stigmasterol 
• 149-73-5 trimethyl orthoformate 
• 83-46-5 β-sitosterol 
• 4651-51-8 campesterol 
• 32345-19-0 24-ethylcholesta-5,22-dien-3β-ol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 83-46-5 β-sitosterol 
• 915-05-9 stigmast-5-en-3-yl acetate 

Relevant academic research and scientific papers

Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives

β-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to β-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of β-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including β-sitosterol, hinders the collection of significant toxicity data on the individual β-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure β-sitosterol is described here, together with the first syntheses and characterisation of pure β-sitosterol oxides. The Royal Society of Chemistry 2005.

Practical and facile route to a functional intermediate from stigmasterol for the synthesis of 1α-hydroxyvitamin D5 and related compounds

As a functional and versatile intermediate for the synthesis of 1α-hydroxyvitamin D5 and related compounds, 1α,2α-epoxy-3β-hydroxystigmasta-5,7-diene was synthesized by a practical and facile 17-step route from stigmasterol in 17% overall yield.

Synthesis and characterization of stigmasterol oxidation products

The synthesis and structural characterization of a series of oxides of stigmasterol is described providing a valuable series of reference standards for these oxides, analogous to the cholesterol oxidation products (COPs) which have been shown to have detrimental biological effects. Biological evaluation of the oxides of phytosterols is significant in the context of increased dietary use of phytosterols in the drive to reduce cholesterol absorption.

Nurotoxic sterol glycosides

The invention relates to compositions for use in animal models of neurodegenerative disease and methods therefor. More particularly, the invention relates to the use of neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof, in animal models of neurodegenerative disease. Neurotoxicity-modulating chromenols can also be used in these animal models in combination with the neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof.

A PROCESS FOR THE PREPARATION OF HIGH PURITY PHYTOSTEROLS FROM DEODOURIZER DISTILLATE FROM VEGETABLE OILS

The present invention provides an isolation process of the pure sterols from the SODD by simple acid catalyzed esterification and the separation of the reagents by distillation and water washing followed by the crystallization of phytosterols and purification. Soybean oil deodorizer distillate (SODD) and distillate from other vegetable oil refining contain free sterols, in addition to steryl esters, tocopherols squalene and unknown compounds. The process is also applicable to other vegetable oil distillate containing more than 1% phytosterols in the free form. Phytosterols thus obtained is of high purity (95-99%) and high yield (80-90%) and contains β-sitosterol, Stigmasterol and campesterol.