104608-47-1

Upstream product

• 24239-18-7 2-<4-(bromomethyl)phenyl>benzothiazole 
• 75889-62-2 fostedil 
• 104608-45-9 Ethyl Hydrogen 4-(Benzothiazol-2-yl)benzylphosphonate 

Downstream Products

• 127881-36-1 (4-Benzothiazol-2-yl-benzyl)-pyrrolidin-1-yl-phosphinic acid ethyl ester 
• 127881-38-3 (4-Benzothiazol-2-yl-benzyl)-piperidin-1-yl-phosphinic acid ethyl ester 
• 127881-39-4 (4-Benzothiazol-2-yl-benzyl)-morpholin-4-yl-phosphinic acid ethyl ester 
• 127881-37-2 (4-Benzothiazol-2-yl-benzyl)-(2,5-dihydro-pyrrol-1-yl)-phosphinic acid ethyl ester 
• 104608-36-8 ethyl (4-benzothiazol-2-ylbenzyl)(2-oxopyrrolidino)phosphinate 
• 104608-42-6 (4-Benzothiazol-2-yl-benzyl)-(2-oxo-oxazolidin-3-yl)-phosphinic acid ethyl ester 
• 127881-46-3 (4-Benzothiazol-2-yl-benzyl)-(2-oxo-imidazolidin-1-yl)-phosphinic acid ethyl ester 
• 127881-45-2 (4-Benzothiazol-2-yl-benzyl)-(2-oxo-thiazolidin-3-yl)-phosphinic acid ethyl ester 
• 104608-37-9 ethyl 4-(benzothiazol-2-yl)benzyl-(2-oxopiperidino)phosphinate 
• 104608-38-0 (4-Benzothiazol-2-yl-benzyl)-(2-oxo-azepan-1-yl)-phosphinic acid ethyl ester 
• 127881-47-4 (4-Benzothiazol-2-yl-benzyl)-(3-methyl-2-oxo-imidazolidin-1-yl)-phosphinic acid ethyl ester 
• 128766-84-7 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester 
• 128766-81-4 Isobutyl Ethyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-88-1 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2,2,2-trifluoro-ethyl ester 

Relevant academic research and scientific papers

Organic phosphorus compounds. IV. Asymmetric 4-(benzothiazol-2-yl)benzylphosphonates as potent calcium antagonistic vasodilators.

Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.

Organic Phosphorus Compounds. 5. (4-Benzothiazol-2-ylbenzyl)amidophosphonate as Potent Calcium Antagonistic Vasodilators

Structural modification of the calcium antagonist fostedil (KB-944) and their coronary vasodilator activity are described.Amidophosphonate 4a-m, lactam amidophosphonate 7a-l, and diamide dilactam 10 were prepared, and their coronary vasodilator activity w