104636-99-9

Upstream product

• 91534-33-7 6-Benzenesulfonyl-5-hydroxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid ethyl ester 
• 91534-34-8 ethyl 1,2,3,6-tetrahydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)-3-acetylbenzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 
• 91534-36-0 2-acetyl-1,2,8,8a-tetrahydro-7-methyl-5-(phenylsulfonyl)cyclopropa-pyrrolo<3,2-e>indol-4(5H)-one 
• 91534-35-9 3-acetyl-1,2,3,6-tetrahydro-5-hydroxy-1-hydroxymethyl-8-methyl-6-phenylsulphonylpyrrolo<3,2-e>indole 
• 91534-32-6 ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 
• 112089-90-4 Methanesulfonic acid 5-benzyloxy-3-(1H-indole-2-carbonyl)-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 
• 58881-45-1 Indole-2-carbonyl chloride 
• 91534-38-2 1,2,8,8a-tetrahydro-7-methylcyclopropapyrrolo<3,2-e>indol-4-(5H)-one 
• 114996-71-3 (1R)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole 
• 122330-65-8 ((R)-5-Benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol 
• 1477-50-5 Indole-2-carboxylic acid 
• 127943-67-3 (R)-6-(1H-indol-2-ylcarbonyl)-8-(chloromethyl)-3,6,7,8-tetrahydro-1-methylbenzo<1,2-b:4,3-b'>dipyrrol-4-ol 
• 110314-49-3 (R)-5-Benzyloxy-1-methanesulfonyloxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carboxylic acid tert-butyl ester 
• 112764-70-2 (R)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole 

Relevant academic research and scientific papers

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (1), are described. Many of these synthetic analogues are significantly more effectiv

Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Unprotected Cyclopropapyrroloindole A Portion Using the 3,3'-Bipyrrole Strategy

The total synthesis of the unprotected A portion of the potent cytotoxic agent CC-1065 1 using the 3,3'-bipyrrole strategy is described.Treatment of ethyl sorbate with (p-tolylsulfonyl)methyl isocyanide (TosMIC)/NaH gave the pyrrole 7, which was N'-phenyl