91534-33-7

Upstream product

• 91534-32-6 ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 

Downstream Products

• 104636-99-9 2-(1H-indol-2-ylcarbonyl)-1,2,8,8a-tetrahydro-7-methylcyclopropapyrrolo<3,2-c>indol-4(5H)-one 
• 91534-36-0 2-acetyl-1,2,8,8a-tetrahydro-7-methyl-5-(phenylsulfonyl)cyclopropa-pyrrolo<3,2-e>indol-4(5H)-one 
• 91534-35-9 3-acetyl-1,2,3,6-tetrahydro-5-hydroxy-1-hydroxymethyl-8-methyl-6-phenylsulphonylpyrrolo<3,2-e>indole 
• 91534-37-1 1,2,8,8a-tetrahydro-7-methyl-5-phenylsulphonylcyclopropapyrrolo<3,2-e>indol-4(5H)-one 
• 91534-34-8 ethyl 1,2,3,6-tetrahydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)-3-acetylbenzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 

Relevant academic research and scientific papers

Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Cyclopropapyrroloindole Portion

Using a regioselective Mannich reaction the 3,3'-bipyrrole (4) is converted into the acid chloride (10), which is transformed into the tricyclic phenol (11); selective reduction of (11) using triethylsilane in trifluoroacetic acid gives (12), which is con

Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Unprotected Cyclopropapyrroloindole A Portion Using the 3,3'-Bipyrrole Strategy

The total synthesis of the unprotected A portion of the potent cytotoxic agent CC-1065 1 using the 3,3'-bipyrrole strategy is described.Treatment of ethyl sorbate with (p-tolylsulfonyl)methyl isocyanide (TosMIC)/NaH gave the pyrrole 7, which was N'-phenyl