104668-15-7

Usage

Uses

Used in Organic Synthesis:
3-FORMYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of chemical entities, making it a versatile building block in the development of new molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-FORMYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key component in the development of new drugs and pharmaceutical products. Its potential biological and pharmacological activities contribute to the exploration of novel therapeutic agents, particularly in the context of drug discovery and design.
Used in Biochemical Research:
3-FORMYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is also utilized in biochemical studies to investigate various biochemical processes and pathways. Its presence in these studies can provide insights into the mechanisms of action and potential interactions with biological systems, furthering our understanding of its applications in medicine and biology.

Upstream product

• 151838-62-9 N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 63006-93-9 3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 243858-66-4 N-tert-butyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-methanol 
• 151838-63-0 (±)-1,1-dimethylethyl 3,4-dihydro-3-(N-methoxy-N-methylcarbamoyl)isoquinoline-2(1H)-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 41994-51-8 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride 

Downstream Products

• 1034607-32-3 C₃₇H₄₅F₂N₃O₄ 
• 1034607-30-1 C₄₄H₅₁F₂N₃O₄ 
• 1034607-41-4 C₄₀H₄₃F₂N₅O₄ 
• 1345968-31-1 C₄₆H₅₄F₂N₄O₅ 
• 1034606-33-1 (S)-2-((S)-3-butyl-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)propanamide 
• 1034606-31-9 C₃₆H₄₃F₂N₃O₃ 
• 1034606-39-7 C₃₂H₃₅F₂N₅O₃ 
• 1345968-38-8 C₃₂H₃₇F₂N₃O₃ 
• 1034606-35-3 (S)-2-((R)-3-acetamido-3-isobutyl-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)-4-phenylbutanamide 
• 1345968-25-3 C₂₆H₂₈F₂N₂O₂ 
• 1034606-41-1 (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol 

Relevant academic research and scientific papers

TIPP: A Highly Potent and Stable Pseudopeptide δ Opioid Receptor Antagonist with Extraordinary δ Selectivity

Pseudopeptide analogues of the δ opioid antagonists H-Tyr-Tic-Phe-Phe-OH (TIPP) and H-Tyr-Tic-Phe-OH (TIP) containing a reduced peptide bond between the Tic2 and Phe3 residues were synthesized.The two compounds, H-Tyr-TicψPhe-

Facile generation of aziridines from the reaction of α-diazoamides with tethered oximino-ethers

In an attempt to prepare azomethine ylide intermediates for cycloaddition reactions with electron deficient olefins, oximino-ethers with tethered α-diazoamide moieties were reacted in the presence of metal catalyst. The reaction resulted in aziridine formation preferentially.

Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1

The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hypertension. Unfortunately, many potent PNMT inhibitors also po

Investigations concerning the organolanthanide and group 3 metallocene-catalyzed cyclization-functionalization of nitrogen-containing dienes

Organolanthanide catalyzed cyclization-silylation of nitrogen-containing polyunsaturated systems allows access to core structures commonly found in naturally occurring alkaloids. Nitrogen-containing dienes with various substitution patterns were investigated. The method was most successful for substrates with terminal alkenes. Cyclization upon pendant 1,1-disubstituted olefins was not realized under various conditions. Interestingly, sterically hindered sulfonamides, which were previously believed to render the catalyst inactive, were actually compatible with the catalyst, thus affording the cyclized products after prolonged reaction times. Variations using fused ring systems were also investigated.

Piperazine- and piperidine-derivatives as melanocortin receptor agonists

The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.

Intramolecular aziridination: Decomposition of diazoamides with tethered imino bonds

(Matrix presented) Of three possible mechanistic pathways, tethered oximino ethers react intramolecularly with diazoamides to produce a diazabicyclo[5.1.0]-hexane aziridine containing skeleton. Several acyclic and cyclic templates were synthesized and reacted with rhodium catalysts to prepare their corresponding annulated aziridines. Anomalous behavior was discovered with the piperidine template, resulting in an aziridination occurring during the attempted diazo-transfer reaction, rather than the catalyzed carbenoid reaction.