10472-95-4

Basic information

• Product Name: 1-phenyl-3-(pyridin-3-yl)propane-1,3-dione
• CAS NO: 10472-95-4
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.2426
• Mol File: 10472-95-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 421.1°C at 760 mmHg
• Flash Point: 209.9°C
• Density: 1.184g/cm³
• Vapor Pressure: 2.67E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 1-phenyl-3-(pyridin-3-yl)propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(pyridin-3-yl)propane-1,3-dione(10472-95-4)
• EPA Substance Registry System: 1-phenyl-3-(pyridin-3-yl)propane-1,3-dione(10472-95-4)

Safety Data

• Hazardous Substances Data: 10472-95-4(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline powder

Molecular weight

263.29 g/mol

Classification

Chalcone derivative, flavonoids

Usage

Synthesis of various pharmaceuticals

Biological activities

Antioxidant, anti-inflammatory, and anticancer properties

Therapeutic applications

Potential treatment of neurological disorders and metabolic diseases

Other potential uses

Fluorescent dye, chemical intermediate in organic synthesis

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 98-86-2 acetophenone 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 932-90-1 Benzaldoxime 
• 142354-39-0 1-phenyl-3-(pyridin-3-yl)prop-2-yn-1-one 
• 100-54-9 pyridine-3-carbonitrile 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 53295-96-8 3-(3-phenyl-propyl)-piperidine 
• 98-86-2 acetophenone 
• 247056-20-8 3-cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 
• 93-89-0 benzoic acid ethyl ester 

Relevant articles and documents

Structure- and Temperature-Dependent Luminescence Properties of Threefold Interpenetrated Networks: Coordination Polymers Based on Dinuclear Gridlike Silver(I) Units

Dinuclear gridlike AgI structural units (1) based on (3-pyridyl)-5-R-pyrazole ligands are extended from oligomers (R = phenyl) to three threefold interpenetrated 3D coordination polymers (R = 3-pyridyl) with cds-a (augmented CdSO4) n

Variations in the blaise reaction: Conceptually new synthesis of 3-amino enones and 1,3-diketones

Organic compounds with 3-amino enone or 1,3-diketone functional groups are extremely important, as they can be converted into a plethora of heterocyclic or carbocyclic compounds, or can be used as ligands in metal complexes. We have achieved a new, easy, straightforward and convenient synthesis of 3-amino enones and 1,3-diketones starting from aryl/heteroaryl/alkyl nitriles and 1-aryl/alkyl 2-bromoethanones. The reaction is a variation of the classical Blaise reaction, and it works with zinc and trimethylsilyl chloride as an activator. By running the hydrolysis of the reaction intermediate with HCl (3 N aq.) at 0-30 °C or at 100 °C, it is possible to form either 3-amino enones or 1,3-diketones, respectively. The newly developed method was used for the synthesis of avobenzone, an ingredient of sun-screen lotions. Furthermore, an easy synthesis of (Z)-3-amino-1-[4-(tertbutyl) phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one, with UV/Vis absorption characteristics similar to those of avobenzone, was also achieved.

Synthesis, characterization and fluorescence properties of boron difluoride pyridyl-β-diketonate derivatives

Five pyridyl-β-diketones were synthesized by Claisen condensation of ethyl nicotinate with various aryl methyl ketones in benzene in the presence of sodium amide as the base, and then reacted with boron trifluoride diethyl etherate in dichloromethane to a