10480-19-0

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 106-40-1 4-bromo-aniline 
• 785-80-8 p-nitrobenzylideneaniline 
• 71-43-2 benzene 
• 780-20-1 N-benzylidene-4-bromoaniline 

Downstream Products

• 10482-32-3 1-(4-bromo-phenyl)-5-(4-nitro-phenyl)-4,5-dihydro-1H-[1,2,3]triazole 
• 143874-39-9 (3R,4S)-1-(4-Bromo-phenyl)-4-(4-nitro-phenyl)-3-phenyl-azetidin-2-one 
• 555-16-8 4-nitrobenzaldehdye 
• 1601-98-5 1,2-bis(4-bromophenyl)diazene 
• 355814-56-1 4-bromo-N-(4-nitrobenzyl)aniline 
• 1393934-75-2 N-(4-bromophenyl)-N-[hydroxy(4-nitrophenyl)methyl]formamide 
• 1266570-70-0 3-(4-bromophenyl)-5-methyl-2-(4-nitrophenyl)thiazolidin-4-one 
• 92884-93-0 1-(4-Bromophenyl)-3-(4-nitrophenyl)-2,2-dichloroaziridine 

Relevant academic research and scientific papers

Montmorillonite as a heterogeneous catalyst in the efficient, mild and one pot synthesis of Schiff bases under solvent-free conditions

A mild and efficient method has been reported for preparation of Schiff base ligands through condensation reaction of various aromatic aldehydes and ketones with different aromatic amines in the presence of montmorillonite as a heterogeneous catalyst under solvent free conditions. The advantages of this friendly, economically, environmentally and mild method are such as; simplicity of the reaction procedure, reusability of catalyst, simple work-up, high product yields and very short reaction times.

Au(I) Catalyzed Synthesis of Densely Substituted Pyrazolines and Dihydropyridines via Sequential Aza-Enyne Metathesis/6π-Electrocyclization

A gold(I) autotandem catalysis protocol is reported for the de novo synthesis of densely substituted pyrazolines and dihydropyridines from the corresponding imine derivatives in a highly regioselective fashion via a one-pot aza-enyne metathesis/6π-electrocyclization sequence. The substituents on the nitrogen atom of the imine perfectly control the reaction pathways from the pivotal 1-azabutadiene intermediate; thus, carbazates were converted into pyrazolines via 6π-electrocyclization of α,β-unsaturated hydrazones, while aryl imines provided dihydropyridines via 6π-electrocyclization of 3-azahexatrienes.

Chemoselective Reduction of the P=O Bond in the Presence of P–O and P–N Bonds in Phosphonate and Phosphinate Derivatives

Chemoselective reduction of the strong P=O bond in the presence of weaker P–O (ester) and P–N (amide) bonds in phosphonic acid derivatives has constituted an unresolved problem in organophosphorus chemistry for years. This long-standing problem is now solved for biologically relevant α-hydroxy and α-amino phosphonic as well as phosphinic acids esters and amides. The reduction of the P=O bond without concomitant scission of the ester and amide bonds is affected by use of BH3, a mild reducing agent, which affords the corresponding borane protected PIII phosphonite and phosphinite derivatives in one step. A mechanistic rationale is proposed for the role played by neighboring OH and NHR groups in facilitating the reduction, and for the observed chemo- and stereoselectivity. The reduction methodology described opens previously unavailable synthetic options in chemistry of α-functionalized phosphonic and phosphinic acids by offering a unique possibility for direct modifications of oxidation level of the P-center in these compounds.

NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF

The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infecti

Synthesis, growth and characterization of 4-bromo-4′-nitrobenzylidene aniline (BNBA): A novel nonlinear optical material with a (3+1)-dimensional incommensurately modulated structure

The organic nonlinear optical material of 4-bromo-4′-nitrobenzylidene aniline (BNBA, C13H9BrN2O2), a new derivative of benzylideneaniline family, was synthesized and purified by repeated recrystallization. Singl

A novel catalyst-free one-pot synthesis of some new N-(α- hydroxybenzyl)formamides by treatment of 2,2-dichloroaziridines with dimethyl sulfoxide and water under neutral conditions

A novel, mild, and efficient method is reported for the preparation of new N-(α-hydroxybenzyl)formamides in excellent yields and appropriate reaction times through the reaction of 2,2-dichloroaziridines with aqueous DMSO as the O-donor under neutral condi

Synthesis and antitubercular activity of some 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones

The compounds 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones were synthesized by condensing 4-substituted anilines with 4-substituted benzaldehydes by using ethanol as solvent. The synthesized compounds were heated with 2-mercaptopropionic acid in excess of benzene. The chemical nature of synthesized compounds have been confirmed by means of IR, NMR and mass data. The synthesized compounds were screened for antitubercular activity. The compounds were subjected to in vitro screening by the tube dilution technique employing the human virulent H37R V strain of M. tuberculosis using isoniazid as a reference standard. The results revealed that the test compounds IIa, IIc, IId, IIe, exhibits remarkable antitubercular activity against H37RV strain of Mycobacterium tuberculosis. The minimum inhibitory concentration (MIC) values were found in the range of 25 to 42 μg/mL.

A simple protocol for direct reductive amination of aldehydes and ketones using potassium formate and catalytic palladium acetate

A method for direct reductive amination of aldehydes and ketones, including α,β-unsaturated carbonyl compounds, has been developed, which requires potassium formate as reductant and palladium acetate as catalyst. Suitable amines include both primary and secondary aliphatic and aromatic amines.

SUBSTITUENT EFFECTS ON THE 31P, 13C, AND 1H NMR CHEMICAL SHIFTS OF SUBSTITUTED DIPHENYL 1-PHENYLAMINO-1-PHENYLMETHANEPHOSPHONATES AND THEIR ANIONS

For a series of thirty-five novel diphenyl 1-phenylamino-1-phenylmethanephosphonates, substituted in the meta and para positions on the anilino and/or aryl ring, 31P chemical shifts show a good linear correlation with Hammett ?n and Taft ?0 parameters, the 31P nucleus being better shielded in the case of electron withdrawing substituents.The same pattern is observed for the phosphonate anions, except when para phenyl substituents can interact with the phosphorus atom by direct resonance.This inverse relationship is due to a field effect of the substituent dipole which polarizes ?-electron clouds in the molecule.A corresponding shift in ?-electron density is likewise observed for 13C resonances of the two diastereotopic phenoxy groups, the phenylamino and phenyl moieties.Vicinal CH-NH coupling is shown to be dependent on the rate of NH proton exchange as influenced by resonance, temperature and solvent effects.