780-20-1

Basic information

• Product Name: 4-Bromo-N-benzylideneaniline
• Synonyms: 4-Bromo-N-(phenylmethylene)benzenamine;4-Bromo-N-benzylideneaniline;N-(4-Bromophenyl)benzenemethanimine;N-Benzylidene-4-bromoaniline;N-Benzylidene-p-bromoaniline;p-Bromo-N-benzylideneaniline
• CAS NO: 780-20-1
• Molecular Formula: C₁₃H₁₀BrN
• Molecular Weight: 260.1292
• Mol File: 780-20-1.mol
• Article Data: 118

Chemical Properties

• Boiling Point: 359 °C at 760 mmHg
• Flash Point: 170.9 °C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 5.06E-05mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 4-Bromo-N-benzylideneaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-N-benzylideneaniline(780-20-1)
• EPA Substance Registry System: 4-Bromo-N-benzylideneaniline(780-20-1)

Safety Data

• Hazardous Substances Data: 780-20-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-N-benzylideneaniline, also known as 4-Bromo-N-(phenylmethylene)aniline, is a chemical compound with the molecular formula C13H10BrN and a molecular weight of 266.13 g/mol. It is a yellow to orange powder at room temperature and is commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. 4-Bromo-N-benzylideneaniline is known for its ability to form stable complexes with various metal ions, making it useful in coordination chemistry. It is also used in the manufacturing of dyes and pigments. However, 4-Bromo-N-benzylideneaniline is known to be a skin and eye irritant and may cause allergic reactions in some individuals, so proper handling and protective equipment are necessary when working with this chemical.

InChI:InChI=1/C13H10BrN/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-10H/b15-10+

Upstream product

• 110-86-1 pyridine 
• 64-17-5 ethanol 
• 15829-45-5 (E)-benzyliden-aniline; compound with bromine (1:2) 
• 106-40-1 4-bromo-aniline 
• 100-51-6 benzyl alcohol 
• 93-58-3 benzoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 2101-88-4 1-azido-4-bromobenzene 
• 100-46-9 benzylamine 
• 1967-25-5 4-bromophenylurea 
• 94-41-7 benzalacetophenone 
• 100-42-5 styrene 
• 586-78-7 para-nitrophenyl bromide 
• 26456-05-3 10-methylacridinium perchlorate 

Downstream Products

• 3489-08-5 (m-nitrobenzylidene)-p-bromoaniline 
• 538-51-2 benzylidene phenylamine 
• 861556-73-2 4-[1-(4-bromo-phenyl)-3,4-diphenyl-[1,3]diazetidin-2-yl]-phenol 
• 2879-83-6 N-benzyl-N-(4-bromophenyl)amine 
• 1689-73-2 N-(p-hydroxybenzylidene)aniline 
• 2028-85-5 (4-bromophenyl)diazonium chloride 
• 23990-54-7 3-(4-bromo-phenyl)-1,1-dioxo-2-phenyl-1λ⁶-thiazolidin-4-one 
• 6017-81-8 N-Benzyliden-N-pikryl-4-brom-anilinium-chlorid 
• 10480-35-0 1-(4-bromophenyl)-4,5-dihydro-5-phenyl-1H-1,2,3-triazole 
• 76086-79-8 4-[(4-Bromo-phenylamino)-phenyl-methyl]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 37871-90-2 (3R,4S)-1-(4-Bromo-phenyl)-3,4-diphenyl-azetidin-2-one 
• 125112-36-9 diethyl cis-<1-(p-bromophenyl)-3-phenyl-2-aziridinyl>phosphonate 
• 75767-89-4 2-(4-Bromo-phenyl)-1-phenyl-2,3-dihydro-1H-isoindole 
• 75767-93-0 2-(4-bromophenyl)-3-phenylisoindolin-1-one 

Relevant articles and documents

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Rhodium catalyzed multicomponent dehydrogenative annulation: one-step construction of isoindole derivatives

A strategy for one-pot synthesis of isoindoles is describedviaa catalytic multicomponent dehydrogenative annulation of diarylimines, vinyl ketones and simple amines. In the presence of a rhodium catalyst and Cu oxidant, four C-H and two N-H bonds are activated along with the formation of one new C-C and two new C-N bonds, leading to a series of isoindole derivatives in good to very high isolated yields.

Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction

The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, for this multistep procedure, the sacrificial phosphine has to be used, resulting in difficulties in the purification process and waste disposal at the same time. Here, we report a redox-neutral azide-alcohol imination methodology enabled by a base-metal nickel PN3 pincer catalyst. The one-step, waste-free, and high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggests a non-metal-ligand cooperation pathway based on the observation of an intermediate and density functional theory calculations.