104834-77-7Relevant academic research and scientific papers
Novel Three-component Coupling Reaction of Carbodiimide, Methyl Hydrogen Maleate, and an Alcohol or Amine: Synthesis of N-Carbamoylaspartic Acid Derivatives
Kishikawa, Keiki,Sankhavasi, Wongsiri,Yoshizaki, Kazumi,Kohmoto, Shigeo,Yamamoto, Makoto,Yamada, Kazutoshi
, p. 1205 - 1210 (2007/10/02)
A novel three-component coupling reaction of methyl hydrogen maleate 1, a carbodiimide 2, and an alcohol or amine gave derivatives of N-carbamoylaspartic acid (3) in moderate to excellent yields.In the coupling, an intramolecular Michael addition of the acylisourea 6 subsequently occurs to give a new intermediate, 2-iminooxazolidin-5-one 7.The addition of alcohol or amine to the second intermediate 7 completes the three-component coupling.
