10488-96-7

Upstream product

• 13960-36-6 5-methyl-2,6-diphenyl-pyrimidin-4-ylamine 
• 1670-14-0 benzamidine monohydrochloride 
• 10488-87-6 ethyl 2-benzoylpropionate 
• 31889-28-8 (E)-1-(1-phenylprop-1-en-1-yl)pyrrolidine 
• 4461-33-0 benzoyl isocyanate 
• 100-47-0 benzonitrile 
• 15969-46-7 2,6-diphenyl-3H-pyrimidin-4-one 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 110-05-4 di-tert-butyl peroxide 
• 75-91-2 tert.-butylhydroperoxide 
• 614-45-9 tert-Butyl peroxybenzoate 

Downstream Products

• 1846-28-2 5-methyl-2,4,6-triphenylpyrimidine 

Relevant academic research and scientific papers

A Novel Ring Transformation of Oxazinones and Azetidinones into Pyrimidinones

Azetidinones or oxazinones, being easily prepared from enamines and acyl isocyanates, were transformed into highly substituted 4(3H)-pyrimidinones upon treatment with ammonium acetate.This novel ring transformation was also accomplished through a one-pot

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

Methyl ketone derivative, and preparation method and applications thereof

The invention discloses a methyl ketone derivative, and a preparation method and applications thereof. The preparation method comprises following steps: a ketone derivative and an organic peroxide are dissolved in a solvent, and reaction is carried out at 80 to 130 DEG C so as to obtain methyl pyrimidone and a methyl pyrimidone derivative. According to the preparation method, the ketone derivative is taken as a starting material; the raw materials are easily and widely available; products of different kinds can be obtained via the preparation method, and can be used directly or used in other further reaction. No metal is involved, so that the preparation method is suitable to be applied in pharmaceutical preparation technology. The preparation method is short in route, mild in reaction conditions, simple in reaction operation and postprocessing process, and high in yield, and is suitable for large-scale production.

Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presen