1846-28-2

Upstream product

• 71722-03-7 2,4,6-triphenyl-2-ethyl-2,3-dihydro-1,3,5-triazine 
• 1670-14-0 benzamidine monohydrochloride 
• 4258-37-1 1,3-diphenyl-2-methylpropene-3-one 
• 673-32-5 1-Phenylprop-1-yne 
• 100-47-0 benzonitrile 
• 1069-83-6 tetraethylaluminoxane 
• 93-54-9 1-Phenyl-1-propanol 
• 100-51-6 benzyl alcohol 
• 98-88-4 benzoyl chloride 
• 53226-42-9 N-cyclopentylbenzamide 
• 5440-69-7 N-isopropylbenzamide 
• 618-39-3 benzamidin 
• 10488-96-7 5-Methyl-2,6-diphenylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Flow reactor approach for the facile and continuous synthesis of efficient Pd@Pt core-shell nanoparticles for acceptorless dehydrogenative synthesis of pyrimidines from alcohols and amidines

Carbon supported Pd@Pt core-shell nanoparticles catalyst was prepared in a flow reactor toachieve enhanced catalytic activities with low Pt loading for the acceptorless dehydrogenative synthesis of pyrimidines. Spectroscopic (XAS analysis) and microscopic (HAADF-STEM) techniques reveled that the core-shell structure was formed by the applied preparation method. The Pd@Pt/PVP (polyvinylpyrrolidone)/C catalyst showed the activity for the three component one pot synthesis of pyrimidines through a series of consecutive reactions including oxidation of alcohols, C[sbnd]C, and C[sbnd]N coupling, followed by heterocyclization and dehydrogenation employing various primary alcohols, secondary alcohols, and amidines. The reaction mechanism on Pd@Pt/PVP/C catalyst was explored by comparison with the control experiments.

Cooperative ruthenium complex catalyzed multicomponent synthesis of pyrimidines

A new set of 2-(2-benzimidazolyl) pyridine ligand based air and moisture stable ruthenium complexes were synthesized and characterized. The catalytic behaviors of these complexes were evaluated towards the multicomponent synthesis of highly substituted py

Electrophilic Activation of Amides for the Preparation of Polysubstituted Pyrimidines

In this article we describe the straightforward synthesis of polysubstituted pyrimidines by electrophilic activation of secondary amides in the presence of alkynes. An unusual mechanistic detour leading to pyridine derivatives as products is also presente

Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good fun

FeCl3-Assisted Niobium-Catalyzed Cycloaddition of Nitriles and Alkynes: Synthesis of Alkyl- and Arylpyrimidines Based on Independent Functions of NbCl5 and FeCl3 Lewis Acids

NbCl5-catalyzed [2 + 2 + 2] cycloaddition of nitriles with alkynes was used to synthesize pyrimidine derivatives. In this reaction, the use of individual Lewis acids, namely NbCl5 and FeCl3, is a key strategy for achieving the reaction using a catalytic amount of NbCl5. The roles of the two Lewis acids were investigated using FT-IR spectroscopy. The results showed that NbCl5 served as an efficient Lewis acid catalyst for nitrile activation, whereas FeCl3 showed stronger Lewis acidity toward pyrimidines, releasing NbCl5 into the catalytic cycle.

Strategy for the synthesis of pyrimidine derivatives: NbCl 5-mediated cycloaddition of alkynes and nitriles

Intermolecular cycloadditions of alkynes (terminal alkynes and internal alkynes) with aryl nitriles were successfully achieved, using an NbCl 5 complex, to give substituted pyrimidine derivatives in high yields with excellent chemo- and regioselectivity.

THE REACTIONS OF TETRAALKYLALUMINOXANES WITH BENZONITRILE

The reactions of benzonitrile with tetraethylaluminoxane and with tetraethylaluminoxane in 1:1 molar ratio were studied.In the case of tetraethylaluminoxane 1,3,5-triphenyl-2,4-diaza-1-aminoheptadiene-1,4, Ph(Et)HCN=C(Ph)N=C(Ph)NH2, was found to be the main product after hydrolysis, 1,3-diphenyl-2-aza-1-aminopentene-1, Ph(Et)HCN=C(Ph)NH2, 2,4,6-triphenylazine-1,3,5; 5-methyl-2,4,6-triphenylpyrimidine, propiophenone and benzaldehyde were also formed.A reaction scheme is proposed.In the case of Me4AL2O, acetophenone was formed as the main product after hydrolysis.