105123-91-9

Upstream product

• 105123-90-8 1-<(2-chloro-4-methyl)phenyl>piperidin-4-one 
• 149-73-5 trimethyl orthoformate 
• 106-49-0 p-toluidine 
• 105123-89-5 1-(4-methylphenyl)piperidin-4-one 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 115012-45-8 1-N-[(2-chloro-4-methyl)phenyl]-4,4-dimethoxypiperidine 
• 105123-88-4 N,N-di-(2-ethoxycarbonylethyl)-p-toluidine 
• 3592-25-4 1,5-dichloropentan-3-one 

Downstream Products

• 115436-35-6 N-[9-{(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-6-(3-chloro-phenoxy)-9H-purin-2-yl]-2-phenyl-acetamide 
• 105123-92-0 2'-O-[1-(2-Chloro-4-methylphenyl)-4-methoxypiperidin-4-yl]uridine 
• 105123-97-5 C₄₁H₄₆Cl₂N₅O₁₇P 
• 105123-95-3 1-[(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 115436-39-0 N-[9-[(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-6-(3-chloro-phenoxy)-9H-purin-2-yl]-2-phenyl-acetamide 
• 115436-44-7 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-4-[1-(2-chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-5-[4-(2,4-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 115436-37-8 4-tert-Butyl-N-{9-[(2R,3R,4R,5R)-3-[1-(2-chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 115436-38-9 4-tert-Butyl-N-{1-[(2R,3R,4R,5R)-3-[1-(2-chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 115436-40-3 1-[(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-4-(2,4-dimethyl-phenoxy)-1H-pyrimidin-2-one 
• 115436-34-5 4-tert-Butyl-N-(9-{(2R,3R,4R,5R)-3-[1-(2-chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 115458-59-8 4-tert-Butyl-N-(1-{(2R,3R,4R,5R)-3-[1-(2-chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 115436-36-7 1-{(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-4-(2,4-dimethyl-phenoxy)-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones

When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,

Protection of hydroxy function with 1-N-aryl-4-alkoxy-piperidin-4-yl

A process for protecting the 2'-hydroxyl of a nucleoside, which can then be used in the chemical synthesis of polyribonucleotides, comprising the reacting of a protected nucleoside of formula I STR1 wherein B is a nucleoside heterocyclic base and R' is a

AN ACETAL GROUP SUITABLE FOR THE PROTECTION OF 2'-HYDROXY FUNCTIONS IN RAPID OLIGORIBONUCLEOTIDE SYNTHESIS

The 1--4-methoxypiperidin-4-yl has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protecting group under mild hydrolytic conditions ; however, under the relatively more drastic conditions required for the complete removal of a 9-phenylxanthen-9-yl (Px) group, the Ctmp protecting group remains virtually intact.