115012-45-8

Upstream product

• 105123-90-8 1-<(2-chloro-4-methyl)phenyl>piperidin-4-one 
• 105123-89-5 1-(4-methylphenyl)piperidin-4-one 
• 67-56-1 methanol 
• 3592-25-4 1,5-dichloropentan-3-one 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 105123-91-9 1-(2-Chloro-4-methylphenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones

When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,

Protection of hydroxy function with 1-N-aryl-4-alkoxy-piperidin-4-yl

A process for protecting the 2'-hydroxyl of a nucleoside, which can then be used in the chemical synthesis of polyribonucleotides, comprising the reacting of a protected nucleoside of formula I STR1 wherein B is a nucleoside heterocyclic base and R' is a