105205-50-3

Upstream product

• 106851-28-9 [3-Amino-4-(2,2-dimethoxy-ethyl)-phenyl]-phenyl-methanone 
• 1670-82-2 Indole-6-carboxylic acid 
• 394653-94-2 6-(Ν-methoxy-N-methyl)-1H-indole-6-carboxamide 
• 100-59-4 phenylmagnesium chloride 
• 100-58-3 phenylmagnesium bromide 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 52415-29-9 6-bromo-1H-indole 
• 106851-23-4 [4-(2,2-Dimethoxy-ethyl)-3-nitro-phenyl]-phenyl-methanone 
• 106851-18-7 (3-Nitro-4-trimethylsilanylethynyl-phenyl)-phenyl-methanone 
• 56107-02-9 4-chloro-3-nitrobenzophenone 
• 99474-21-2 (E)-2-(4-bromo-2-nitrophenyl)-N,N-dimethylethyleneamine 
• 60956-26-5 4-bromo-2-nitrotoluene 

Downstream Products

• 1433194-53-6 ethyl 3-{4-[2-(6-benzoylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate 
• 1433194-61-6 C₂₈H₂₇NO₅ 
• 1433194-68-3 ethyl 2-ethoxy-3-{4-[2-(6-{[E-methoxyimino]phenylmethyl}indol-1-yl)ethoxy]phenyl}propionate 
• 1439717-82-4 ethyl 2-ethoxy-3-{4-[2-(6-{[Z-methoxyimino]phenylmethyl}indol-1-yl)ethoxy]phenyl}propionate 
• 1433194-85-4 6-{[(E)-methoxyimino]phenylmethyl}-1H-indole 
• 1439721-30-8 6-{[(Z)-methoxyimino]phenylmethyl}-1H-indole 

Relevant academic research and scientific papers

Preparation method of 6-benzoyl-1H-indole

The invention relates to the technical field of medical and chemical intermediates and in particular relates to a preparation method of 6-benzoyl-1H-indole. The preparation method comprises the following steps: taking 6-indolecarboxylic acid which is low

Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity

Compounds that simultaneously activate peroxisome proliferator-activated receptor (PPAR) subtypes α and γ have the potential to effectively treat dyslipidemia and type2 diabetes (T2D) in a single pharmaceutically active molecule. The frequently observed side effects of selective PPARγ agonists, such as edema and weight gain, were expected to be overcome by using additive PPARα activity, leading to dual PPARα/γ agonists with balanced activity for both subtypes. Herein we report the discovery, synthesis, and optimization of a new series of α-ethoxyphenylpropionic acid bearing 5- or 6-substituted indoles. The incorporation of oxime ethers on the carbonyl portion of the benzoyl group can bring the PPARα/γ potency ratio equal to or slightly greater than one, as is the case for compounds 20c and 21a. Compound 20c shows high efficacy in an ob/ob mouse model of T2D and dyslipidemia, similar to that of rosiglitazone and tesaglitazar, but with a significant increase in body weight gain. In contrast, compound 21a, less potent as a dual PPARα/γ activator than 20c, showed an interesting pharmacological profile, as it elicits a decrease in body weight relative to reference compounds.

6-SUBSTITUTED INDOLES FROM o-HALONITROBENZENES

o-Chloro- and o-bromonitrobenzenes are efficiently converted to 6-substituted indoles in a four step synthesis, proceeding through o-trimethylsilylethynylnitrobenzenes, o-nitrophenylacetaldehyde dimethylacetals and o-aminophenylacetaldehyde dimethylacetal

Metal-Halogen Exchange of Bromoindoles. A Route to Substituted Indoles

The 4-, 5-, 6-, and 7-bromoindoles, conveniently synthesized by the Batcho-Leimgruber process, serve as efficient precursors to regiochemically pure lithiated indoles.Metal-halogen exchange was most effective if potassium hydride was used first to remove the acidic indole NH, and tert-butyllithium was used then to effect metal-halogen exchange.The resulting indolyl organometallic reagents react with a variety of electrophiles to give regioisomerically pure acylated indoles.