1052114-83-6

Basic information

• Product Name: 5-BroMo-4-hydroxynicotinic acid
• Synonyms: 5-BroMo-4-hydroxynicotinic acid;5-BroMo-4-hydroxypyridin-3-carboxylic acid;5-bromo-4-hydroxypyridine-3-carboxylic acid
• CAS NO: 1052114-83-6
• Molecular Formula: C₆H₄BrNO₃
• Molecular Weight: 218.00486
• Mol File: 1052114-83-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 452.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.985±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -0.46±0.14(Predicted)
• CAS DataBase Reference: 5-BroMo-4-hydroxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-4-hydroxynicotinic acid(1052114-83-6)
• EPA Substance Registry System: 5-BroMo-4-hydroxynicotinic acid(1052114-83-6)

Safety Data

• Hazardous Substances Data: 1052114-83-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-hydroxynicotinic acid is a chemical compound that is derived from nicotinic acid. It is a white to off-white crystalline powder that is used in the synthesis of various pharmaceuticals and agrochemicals. 5-BroMo-4-hydroxynicotinic acid has a bromine atom and a hydroxyl group attached to the nicotinic acid structure, making it a derivative of nicotinic acid. It is commonly used as a building block in the synthesis of potential bioactive compounds and drug candidates. Additionally, it has been reported to have antibacterial and antifungal activities, making it a valuable compound in the development of new pharmaceuticals and agrochemicals.

InChI:InChI=1S/C7H6BrNO3/c1-12-7(11)4-2-9-3-5(8)6(4)10/h2-3H,1H3,(H,9,10)

Upstream product

• 609-70-1 4-hydroxynicotinic acid 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 67848-59-3 4-piperidone-3-carboxylic acid ethyl ester 
• 25813-25-6 3,5-dibromo-4-hydroxypyridine 
• 124-38-9 carbon dioxide 
• 109-72-8 n-butyllithium 

Downstream Products

• 1175512-08-9 methyl 5-bromo-4-oxo-1,4-dihydropyridine-3-carboxylate 
• 1449299-95-9 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-6'-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydro-3,3'-bipyridine-5-carboxamide 

Relevant articles and documents

Preparation method of 4-methoxy-5-cynao-3-pyridinecarboxylic acid methyl ester

The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of 4-methoxy-5-cynao-3-pyridinecarboxylic acid methyl ester (shown in a formula I) and an intermediate thereof. According to the preparation method, 4-hydroxynicotinic acid is used as a starting raw material, and through the three reactions of bromination, methylation and cyano-substitution, the target product 4-methoxy-5-cynao-3-pyridinecarboxylic acid methyl ester (shown in the formula I) is prepared, wherein in the cyano-substitution step, cuprous cyanide is adopted to perform cyano-substitution which is better than substitutive synthesis through other cyano-compounds. Through the preparation method, the raw materials are easy and convenient to obtain, reaction conditions are mild, aftertreatment is simple, and therefore the preparation method is suitable for industrial production.

Pyridone Derivatives

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.