1053696-34-6

Basic information

• Product Name: (3aR,4R,6aR)-methanesulfonic acid 6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester
• Synonyms: (3aR,4R,6aR)-methanesulfonic acid 6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester
• CAS NO: 1053696-34-6
• Molecular Weight: 372.415
• Mol File: 1053696-34-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3aR,4R,6aR)-methanesulfonic acid 6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,4R,6aR)-methanesulfonic acid 6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester(1053696-34-6)
• EPA Substance Registry System: (3aR,4R,6aR)-methanesulfonic acid 6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester(1053696-34-6)

Safety Data

• Hazardous Substances Data: 1053696-34-6(Hazardous Substances Data)

Upstream product

• 491577-97-0 (3aR,4R,6aR)-(6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yloxy)-tert-butyl-diphenyl-silane 
• 117307-62-7 (3aR,6aR)-6-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-one 
• 124-63-0 methanesulfonyl chloride 
• 491578-02-0 (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 
• 491578-01-9 ((3aR,4R,6aR)-6-(benzyloxymethyl)-5-iodo-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)diphenylsilane 
• 491578-00-8 (3aS,4R,6aR)-6-benzyloxymethyl-5-iodo-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol 
• 491577-99-2 (3aR,6aR)-6-benzyloxymethyl-5-iodo-2,2-dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 

Downstream Products

• 491578-04-2 (3aS,4S,6aR)-9-(6-benzyloxymethyl-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-9H-purin-6-ylamine 

Relevant articles and documents

X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues

The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation

Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase

Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78 °C). Fluoroneplanoc