105426-91-3

Upstream product

• 7081-78-9 1-chloroethyl ethyl ether 
• 119987-30-3 (3Z,7E)-4-Dimethoxymethyl-8-methyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-1-(5-trimethylsilanyl-furan-3-yl)-deca-3,7-dien-1-ol 
• 4412-91-3 furan-3-methanol 
• 18665-81-1 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-en-1-ol 
• 29550-53-6 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-enyl)pent-2-enyl bromide 
• 89861-09-6 (2-Phenylsulfanyl-furan-3-yl)-methanol 
• 94742-48-0 2-phenylthio-5-trimethylsilyl-furan-3-methanol 
• 105426-86-6 (2Z,6E)-3-Dimethoxymethyl-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienoic acid tert-butyl ester 
• 105426-94-6 (2Z,6E)-3-Dimethoxymethyl-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dien-1-ol 
• 105426-85-5 (E)-1,1-Dimethoxy-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-oct-5-en-2-one 
• 4179-00-4 Methyl (E)-3-methyl-5-(2,6,6-trimethylcyclohexen-1-yl)-2-pentenoate 
• 112503-50-1 2-((3E,7Z)-9-Chloro-7-dimethoxymethyl-3-methyl-nona-3,7-dienyl)-1,3,3-trimethyl-cyclohexene 
• 105426-90-2 {4-[(1-Ethoxy-ethoxy)-tributylstannanyl-methyl]-furan-2-yl}-trimethyl-silane 

Downstream Products

• 80388-51-8 manoalide-2-methyl ether 
• 75088-80-1 5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one 
• 105498-76-8 seco-manoalide 
• 75088-80-1 manoalide 
• 105426-92-4 4-[(3Z,7E)-4-Dimethoxymethyl-1-(1-ethoxy-ethoxy)-8-methyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-deca-3,7-dienyl]-5-hydroxy-5H-furan-2-one 

Relevant academic research and scientific papers

HIGHLY EFFICIENT TOTAL SYNTHESIS OF MANOALIDE AND SECO-MANOALIDE VIA Pd(0) CATALYZED COUPLING OF ALLYLHALIDE WITH CO AND 2-SILYL-4-STANNYLFURAN

Total synthesis of manoalide and seco-manoalide from an allylchloride derivative was achieved by 6 steps in 56.4percent overall yield by Pd(0) catalyzed coupling with CO and 2-trimethylsilyl-4-tributylstannylfuran followed by chemoselective oxidation of 2-trimethylsilylfuran with 1O2.

TOTAL SYNTHESIS OF MANOALIDE AND SECO-MANOALIDE

The first synthesis of manoalide and seco-manoalide from methyl 7,8-dihydro-β-ionylidene acetate was achieved in high yield by the new method utilizing regiospecific singlet oxigen oxidation of 3-alkenyl-5-trimethylsilylfuran to β-alkenyl-γ-hydroxybutenol