10543-56-3

Basic information

• Product Name: N-acetyl-2-phenylacetamide
• CAS NO: 10543-56-3
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.1998
• Mol File: 10543-56-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 341.6°C at 760 mmHg
• Flash Point: 151.1°C
• Density: 1.119g/cm³
• Vapor Pressure: 7.94E-05mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: N-acetyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-2-phenylacetamide(10543-56-3)
• EPA Substance Registry System: N-acetyl-2-phenylacetamide(10543-56-3)

Safety Data

• Hazardous Substances Data: 10543-56-3(Hazardous Substances Data)

Upstream product

• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 103-82-2 phenylacetic acid 
• 75-05-8 acetonitrile 
• 10026-13-8 phosphorus pentachloride 
• 75115-15-0 3-bromo-4-phenyl-but-3-en-2-one oxime 
• 100193-21-3 2-acetamido-2-benzylmalonic acid 
• 140-29-4 phenylacetonitrile 
• 1641-36-7 n-butylammonium acetate 
• 103-81-1 Benzeneacetamide 
• 150-30-1 Phenylalanine 
• 4870-65-9 2-bromophenylacetic acid 
• 5469-44-3 2-methyl-4-benzyl-4H-oxazolin-5-one 

Downstream Products

• 1361032-75-8 3-benzyl-5-methyl-1-phenyl-1H-1,2,4-triazole 
• 1361032-74-7 5-benzyl-3-methyl-1-phenyl-1H-1,2,4-triazole 

Relevant articles and documents

Ag-Catalyzed Chemoselective Decarboxylative Mono- and gem-Difluorination of Malonic Acid Derivatives

Malonic acid derivatives have been successfully applied in a Ag-catalyzed decarboxylative fluorination reaction, providing an unprecedented route to either gem-difluoroalkanes or α-fluorocarboxylic acids by the judicious selection of base and solvent. This reaction features the use of readily available starting materials, tunable chemoselectivity and good functional group compatibility as well as gram-scale synthetic capability. The advantage of using malonic acid derivatives in this radical decarboxylative functionalization is further highlighted by the facile transformations of the α-fluorocarboxylic acid to valuable fluorine-containing compounds. Preliminary mechanistic studies suggest that an α-carboxylic acid radical is involved in this reaction.

N-Butylammonium carboxylates/Tf2O: Ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction

We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure.

Biologically Active Metabolites of Fungi, I.-Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analogous Open-Chain Imides

The mixed open-chain imide N-(3-chloro-4-hydroxyphenylacetyl)fumarate (1), named coniothyriomycin, was isolated as a metabolite of the fungus Coniothyrium.The natural product 1 and the analoguos imides 13-15 and 22-24 have been synthesized by base-catalyzed condensation of the imidates 12a-f with acid chlorides 6a-c or the mixed anhydride 21.The compounds 1 and 13-15 were shown to posess remarkable fungicidal and herbicidal activities in short-termed tests. Key Words: Fungal metabolites / Imides, open-chain / Fungicidal activity / Coniothriomycin