105449-77-2

Upstream product

• 26826-81-3 benzenemethanesulfenyl chloride 
• 78-84-2 isobutyraldehyde 
• 6651-34-9 2-methyl-1-(trimethylsilyloxy)-1-propene 
• 150-60-7 dibenzyl disulphide 
• 100-53-8 phenylmethanethiol 
• 13206-46-7 2-bromo-2-methylpropanal 
• 3492-64-6 sodium benzylmercaptide 

Downstream Products

• 335279-92-0 ethyl-4-benzylsulfanyl-3-hydroxy-4-methyl-3-hydroxypentanoate 
• 335279-95-3 ethyl 4-benzylsulfanyl-2,4-dimethyl-3-hydroxypentanoate 
• 1170669-10-9 C₂₈H₃₂N₂O₂S 
• 1170669-14-3 ethyl N-acetyl-N-benzyl-3-(benzylthio)valylglycinate 
• 1170669-25-6 ethyl N-{(4S)-4-(benzyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-3-(benzylthio)valylglycinate 
• 1170669-19-8 ethyl N-{(4S)-4-(methyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-3-(benzylthio)valylglycinate 
• 1170669-26-7 benzyl (2S)-5-{benzyl[2-(benzylthio)-2-methyl-1-{[(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)methyl]carbamoyl}propyl]amino}-2-[(tert-butoxycarbonyl)amino]-5-oxopentanoate 
• 878893-21-1 S-benzyl-DL-penicillamine nitrile 
• 159000-75-6 S-benzyl-D,L-penicillamine 
• 126361-23-7 Sodium; 17,18-bis-(2-benzylsulfanyl-2-methyl-propylamino)-octadecanoate 
• 126361-22-6 Sodium; 16,17-bis-(2-benzylsulfanyl-2-methyl-propylamino)-heptadecanoate 
• 126361-21-5 Sodium; 15,16-bis-(2-benzylsulfanyl-2-methyl-propylamino)-hexadecanoate 
• 126361-17-9 17,18-Bis-(2-benzylsulfanyl-2-methyl-propylamino)-octadecanoic acid ethyl ester; hydrochloride 
• 126361-16-8 16,17-Bis-(2-benzylsulfanyl-2-methyl-propylamino)-heptadecanoic acid ethyl ester; hydrochloride 

Relevant academic research and scientific papers

A Joint Experimental-Computational Comparative Study of the Pd0-Catalysed Reactions of Aryl Iodides and Aldehydes with N, O, and S Tethers

The influence of the heteroatom (nitrogen, oxygen, and sulfur) on the course of the palladium-catalysed intramolecular reactions of aryl iodides and aldehydes having heteroatom-containing tethers has been explored by an extensive experimental-computationa

One-step synthesis of N-acetylcysteine and glutathione derivatives using the Ugi reaction

Fully protected natural and unnatural N-acetylcysteine, dipeptide Cys-Gly, glutathione, and homoglutathione derivatives were synthesized by the Ugi four-component reaction using various benzylthio aldehydes and ketones as carbonyl building blocks. The scope and limitations of the method were investigated. Formation of imidazoline by-products in the Ugi reaction was discussed. 2,2,2-Trifluoroethanol was shown to be a superior reaction media than methanol in some reactions. Also, the 4-methyl-2,6,7-trioxabicyclo[2.2.2]octyl derivative (OBO-ester) of isocyanoacetic acid was shown to be superior to use than ethyl isocyanoacetate as a peptide synthesis precursor in cases when higher reactivity of an isocyanide is required.

THIA-EPOTHILONE DERIVATIVES FOR THE TREATMENT OF CANCER

The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.

Scope and limitations of the [1,2]-alkylsulfanyl (SMe, SEt and SCH2Ph) and sulfanyl (SH) migration in the stereospecific synthesis of substituted tetrahydrofurans

Acid catalysed rearrangement of a series of 4-RS-1,3-diols (R = Me, Et, Bn and H) with toluene-p-sulfonic acid in dichloromethane gives stereospecifically substituted tetrahydrofurans via a [1,2]-SR shift in near quantitative yield. We comment on the structural variation of the migrating (RS) substituent and that of the migration origin and terminus on the outcome of the title reaction. We also report on the surprising similarity between an alkylsulfanyl (RS) and sulfanyl (SH) migrating group.

7,10-Bis(2-mercapto-2-methyl)propyl-7,10-diazapalmitic acid: A novel, N2S2 ligand for technetium-99m

7,10-Bis(2-mercapto-2-methyl)propyl-7,10-diazapalmitic acid (7) was synthesized and evaluated as a new ligand for technetium-99m (99mTc). The title fatty acid analog, an achiral, bis(aminoethanethiol) derivative in which the amines are tertiary, gave a stable complex with 99mTc. The biodistribution of 99mTc-labeled 7 in rats is reported.