105452-15-1

Basic information

• Product Name: (S)-(-)-4-METHYLMANDELONITRILE
• Synonyms: (S)-(-)-4-METHYLMANDELONITRILE
• CAS NO: 105452-15-1
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 105452-15-1.mol
• Article Data: 46

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-(-)-4-METHYLMANDELONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-4-METHYLMANDELONITRILE(105452-15-1)
• EPA Substance Registry System: (S)-(-)-4-METHYLMANDELONITRILE(105452-15-1)

Safety Data

• Hazardous Substances Data: 105452-15-1(Hazardous Substances Data)

Usage

General Description

(S)-(-)-4-Methylmandelonitrile is a chemical compound with the molecular formula C9H9NO. It is a chiral compound, meaning it has a non-superimposable mirror image, and is commonly used in the synthesis of pharmaceuticals and agrochemicals. (S)-(-)-4-METHYLMANDELONITRILE has a sweet, almond-like odor and is often used in the flavor and fragrance industry. It is also a versatile intermediate in organic synthesis, with applications in the production of fine chemicals and pharmaceuticals. Additionally, (S)-(-)-4-Methylmandelonitrile has been studied for its potential medicinal properties, including its role as an anti-cancer agent. Due to its diverse applications, this compound has been the focus of extensive research in the fields of chemistry, pharmacology, and material science.

Upstream product

• 151-50-8 potassium cyanide 
• 104-87-0 4-methyl-benzaldehyde 
• 773837-37-9 sodium cyanide 
• 75599-81-4 α-acetoxy-2-(4-methylphenyl)acetonitrile 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 136983-96-5 (S)-2-acetyloxy-2-(4-methylphenyl)acetonitrile 
• 191720-20-4 (S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile 
• 620-23-5 m-tolyl aldehyde 
• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 74-90-8 hydrogen cyanide 
• 108-05-4 vinyl acetate 

Downstream Products

• 136983-96-5 (S)-2-acetyloxy-2-(4-methylphenyl)acetonitrile 
• 18584-20-8 (S)-2-hydroxy-2-(p-tolyl)acetic acid 

Relevant articles and documents

Multivariate Metal-Organic Frameworks as Multifunctional Heterogeneous Asymmetric Catalysts for Sequential Reactions

The search for versatile heterogeneous catalysts with multiple active sites for broad asymmetric transformations has long been of great interest, but it remains a formidable synthetic challenge. Here we demonstrate that multivariate metal-organic frameworks (MTV-MOFs) can be used as an excellent platform to engineer heterogeneous catalysts featuring multiple and cooperative active sites. An isostructural series of 2-fold interpenetrated MTV-MOFs that contain up to three different chiral metallosalen catalysts was constructed and used as efficient and recyclable heterogeneous catalysts for a variety of asymmetric sequential alkene epoxidation/epoxide ring-opening reactions. Interpenetration of the frameworks brings metallosalen units adjacent to each other, allowing cooperative activation, which results in improved efficiency and enantioselectivity over the sum of the individual parts. The fact that manipulation of molecular catalysts in MTV-MOFs can control the activities and selectivities would facilitate the design of novel multifunctional materials for enantioselective processes.

Enantioselective cyanosilylation of aldehydes catalyzed by a multistereogenic salen-Mn(III) complex with a rotatable benzylic group as a helping hand

A multistereogenic salen-Mn(iii) complex bearing an aromatic pocket and two benzylic groups as helping hands was found to be efficient in the catalysis of asymmetric cyanosilylation. The salen-Mn catalyst partially mimics the functions of biocatalysts by

Enantioselective cyanosilylation of aldehydes catalyzed by novel camphor derived Schiff bases-titanium(IV) complexes

Five tridentate Schiff bases have been prepared from (1R,2S,3R,4S)-3-amino- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol and salicylaldehydes. X-ray structure investigation revealed differences in their molecular conformation, and their titanium(IV) complexes