105467-77-4 Usage
Structure
Unique polycyclic structure
Applications
a. Medical and research applications
b. Potential anticancer properties
c. Anti-malarial agent
Mechanism of Action
Potent inhibitor of DNA topoisomerase II
DNA Interaction
Disrupts DNA structure and function
Tumor Cell Death
Induces tumor cell death by disrupting DNA
Plasmodium falciparum
Inhibits growth of the parasite
Toxicity
Known to be toxic and mutagenic
Laboratory Safety
Care must be taken when handling and using in laboratory settings
Check Digit Verification of cas no
The CAS Registry Mumber 105467-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,4,6 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 105467-77:
(8*1)+(7*0)+(6*5)+(5*4)+(4*6)+(3*7)+(2*7)+(1*7)=124
124 % 10 = 4
So 105467-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H17N/c1-3-7-16-14(5-1)9-11-20-18(16)13-19-17-8-4-2-6-15(17)10-12-21(19)22-20/h1,3,5,7,9-13H,2,4,6,8H2
105467-77-4Relevant articles and documents
Synthesis of Potential Metabolites of Dibenzacridine: Dihydro Diols and Phenols
Rosario, Christopher A.,Holder, Gerald M.,Duke, Colin C.
, p. 1064 - 1072 (2007/10/02)
The potential trans dihydro diol metabolites of the carcinogen dibenzacridine (1) were prepared.The dihydro diols trans-1,2-dihydroxydibenzacridine (12) and trans-3,4-dihydro-3,4-dihydroxydibenzacridine (13) were prepared by Prevost reactio
