1055901-15-9

Basic information

• Product Name: 2-(5-bromo-2-iodophenyl)acetonitrile
• Synonyms: 2-(5-bromo-2-iodophenyl)acetonitrile
• CAS NO: 1055901-15-9
• Molecular Weight: 321.943
• Mol File: 1055901-15-9.mol

Chemical Properties

• CAS DataBase Reference: 2-(5-bromo-2-iodophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-bromo-2-iodophenyl)acetonitrile(1055901-15-9)
• EPA Substance Registry System: 2-(5-bromo-2-iodophenyl)acetonitrile(1055901-15-9)

Safety Data

• Hazardous Substances Data: 1055901-15-9(Hazardous Substances Data)

Usage

Type of compound

Nitrile

Elements present

Carbon (C), Hydrogen (H), Bromine (Br), Iodine (I)

Usage

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds

Applications

Medicinal chemistry, drug development, and various industrial and research applications

Properties

Versatile reactivity, ability to participate in a wide range of chemical reactions, valuable building block

Upstream product

• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 
• 1261817-10-0 4-bromo-2-(chloromethyl)-1-iodobenzene 
• 1878-67-7 3-Bromophenylacetic acid 
• 702641-01-8 2-(5-bromo-2-iodophenyl)acetic acid 
• 495414-06-7 4-bromo-2-(bromomethyl)-1-iodobenzene 

Downstream Products

• 702641-01-8 2-(5-bromo-2-iodophenyl)acetic acid 

Relevant articles and documents

Palladium(II)-Catalyzed Annulation of Alkynes with 2-(Cyanomethyl)phenylboronates Leading to 3,4-Disubstituted 2-Naphthalenamines

1,2-Bis(diphenylphosphino)ethane (dppe)-ligated palladium(II) complexes catalyze the annulation of internal alkynes with 2-(cyanomethyl)phenylboronates to provide 3,4-disubstituted-2-naphthalenamines in good yields. The annulation reaction proceeds under mild and neutral conditions and requires methanol as an essential solvent. In addition to symmetrical alkynes, unsymmetrical alkynes substituted by aryl, alkyl, and alkynyl groups participate in the annulation to afford the corresponding 2-naphthalenamines with electron-withdrawing sp2- and sp-carbons preferentially located at the C-3 position. Substituents including an alkyl or alkoxy group on the cyanomethyl moiety and a halogen atom on the benzene ring in the boronates are compatible with the reaction conditions. The annulation proceeds through the transmetalation of the palladium(II) complexes with the boronates and alkyne insertion followed by nucleophilic addition of the generated alkenylpalladium(II) species to the intramolecular cyano group. Stoichiometric reactions revealed that the methanol solvent was effective for both transmetalation and catalyst regeneration.

Efficient synthesis of heterocyle-fused β-naphthylamines via intramolecular addition to a cyano group initiated by nucleopalladation of alkynes

A palladium(II)-catalyzed efficient synthesis of heterocycle-fused-naphthylamines was accomplished via nucleophilic addition of a carbon-palladium bond to the intramolecular cyano group initiated by nucleopalladation (oxypalladation or aminopalladation) o

SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS

Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3-C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.