10565-20-5

Basic information

• Product Name: phenyl dichloroacetate
• Synonyms: Phenyl dichloroacetate
• CAS NO: 10565-20-5
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.038
• Mol File: 10565-20-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 246.9°C at 760 mmHg
• Flash Point: 102.4°C
• Density: 1.365g/cm³
• Vapor Pressure: 0.0265mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: phenyl dichloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl dichloroacetate(10565-20-5)
• EPA Substance Registry System: phenyl dichloroacetate(10565-20-5)

Safety Data

• Hazardous Substances Data: 10565-20-5(Hazardous Substances Data)

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 108-95-2 phenol 
• 10112-13-7 phenyl trichloroacetate 
• 16967-79-6 trichloroethylene epoxide 
• 42345-82-4 (E)-1,2-dichloro-1-ethoxy-ethene 
• 4124-30-5 dichloroacetic anhydride 

Downstream Products

• 79-43-6 dichloro-acetic acid 
• 108-95-2 phenol 
• 6338-19-8 (E)-but-2-enedioic acid diphenyl ester 
• 7242-17-3 (Z)-but-2-enedioic acid diphenyl ester 
• 31804-17-8 Phosphoric acid (E)-2-chloro-1-phenoxy-vinyl ester diethyl ester 
• 100191-70-6 dichloro-acetic acid-(1,2,3,4,5,6-hexachloro-cyclohexyl ester) 

Relevant articles and documents

Secondary valence force catalysis. 3. The apparent abnormal reactivity of anionic nucleophilic reagents toward acyl-activated esters.

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Design, synthesis, molecular docking, biological evaluations and QSAR studies of novel dichloroacetate analogues as anticancer agent

Dichloroacetate (DCA) as a mitochondria-targeting small molecule, through inhibition of pyruvate dehydrogenase kinases (PDK1-4), promotes mitochondria-regulated apoptosis and hence, inhibits tumour growth and reduces its proliferation. In this study, a series of novel N-aryl-2,2-dichloroacetamide and aryl-2,2-dichloroacetate derivatives were designed and synthesized. Their cytotoxic activities against various human cancer cell lines including A549, HCA-7, MCF-7, MDA-MB-231, KB and SKOV3 were evaluated. These compounds showed satisfactory potencies with much higher anticancer activity than the parent compound DCA, against the studied cancer cell lines. Molecular docking studies were also done to find their binding site and types of their interactions with PDKs isoenzymes. Among the synthesized compounds, 2,2-dichloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide (f1) can also induce A549 cells apoptosis. Therefore, compound f1 might have a potential value for further study in drug development. QSAR studies of this class of compounds were also explored using a collection of chemometrics methods.

METHOD FOR PRODUCING CARBONATE COMPOUND AND METHOD FOR PRODUCING AROMATIC POLYCARBONATE

The present invention relates to a method for producing a carbonate compound containing: a first step of reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (21) or a compound represented by the following Formula (22) to obtain a reaction mixture containing a carbonate compound, and a second step of bringing the reaction mixture containing a carbonate compound into contact with a strongly basic compound, in which R1 represents a monovalent organic group, and R2 represents a divalent organic group.