105669-53-2

Basic information

• Product Name: N-(2-DIMETHYLAMINOETHYL)-N-METHYLFORMAM&
• Synonyms: N-[2-(Dimethylamino)ethyl]-N-methylformamide;N-(2-(Dimethylamino);N-(2-DIMETHYLAMINOETHYL)-N-METHYLFORMAM&;N-Formyl-N,N',N'-trimethylethylenediamine
• CAS NO: 105669-53-2
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.19
• Product Categories: Organic Building Blocks;Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis
• Mol File: 105669-53-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 218-219 °C(lit.)
• Flash Point: 159 °F
• Appearance: /
• Density: 0.936 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.104mmHg at 25°C
• Refractive Index: n20/D 1.4570(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-DIMETHYLAMINOETHYL)-N-METHYLFORMAM&(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-DIMETHYLAMINOETHYL)-N-METHYLFORMAM&(105669-53-2)
• EPA Substance Registry System: N-(2-DIMETHYLAMINOETHYL)-N-METHYLFORMAM&(105669-53-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 105669-53-2(Hazardous Substances Data)

Usage

Uses

N-(2-Dimethylaminoethyl)-N-methylformamide is a pyridoneamide derivative that is used as a focal adhesion kinase inhibitors and their use for the treatment of cancer.

InChI:InChI=1/C6H14N2O/c1-7(2)4-5-8(3)6-9/h6H,4-5H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 110-70-3 N,N`-dimethylethylenediamine 
• 124-38-9 carbon dioxide 
• 142-25-6 N,N',N'-trimethylenediamine 
• 64-18-6 formic acid 

Downstream Products

• 100-52-7 benzaldehyde 
• 158669-26-2 4-iodo-2-methoxynicotinaldehyde 
• 174092-75-2 4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde 

Relevant articles and documents

Recyclable Oxofluorovanadate-Catalyzed Formylation of Amines by Reductive Functionalization of CO2 with Hydrosilanes

An efficient method has been developed for the reductive amination of CO2 by using readily available and recyclable oxofluorovanadates as catalysts. Various amines are transformed into the desired N-formylated products in moderate to excellent yields at room temperature in the presence of phenylsilane. Mechanistic studies based on in situ infrared spectroscopy suggest a reaction pathway initiated through F?Si interactions. The activated phenylsilane allows for CO2 insertion to produce phenylsilyl formate, which undergoes attack by the amine to generate the target product.

Condensation of Alkanediamines with Formaldehyde; Intramolecular Disproportionation of N-Hydroxymethyl Groups into N-Methyl and N-Formyl Groups

The condensation of α,ω-alkanediamines NH2(CN2)nNH2 with aqueous formaldehyde has been studied by NMR spectroscopy of isolated products and of product mixtures.The condensation was reversible and gave products of widely different types depending on alkane chain length: bicyclic oxadiaza compounds (n = 2, 3, 4), a tricyclic tetraaza compound (n = 2), a quinquecyclic octaaza compound (n = 3), two-dimensional polymers (n = 4, 5).A slow irreversible rearrangement gave in two cases (n = 3, 4), unicyclic 1-formyl-3-methyl-1,3-diaza compounds.The condensation of N,N'-dimethyl-α,ω-alkandediamines CH3NH(CH2)nNHCH3 with aqueous formaldehyde was also studied.The reversible formation of simple unicyclic diaza compounds was observed in all cases (n = 2, 3, 4), but in one case (n = 2) there was again a slow irreversible rearrangement to the N-formyl-N,N'N'-trimethyl derivative.The rearrangement reaction involves a hydride shift and is strictly intramolecular.The conditions for its occurrence can be understood on a conformational basis.