1056877-14-5

Usage

Uses

Used in Pharmaceutical Industry:
3-hydroxy-1,5-naphthyridine-4-carbaldehyde is used as a building block in the synthesis of various bioactive molecules for its potential as an antiviral or antibacterial agent. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 3-hydroxy-1,5-naphthyridine-4-carbaldehyde serves as a key component in the creation of bioactive molecules, which can be utilized in the development of pesticides or other agricultural chemicals to protect crops and enhance yield.
Used in Research Applications:
3-hydroxy-1,5-naphthyridine-4-carbaldehyde is used as a fluorescent probe for detecting metal ions, particularly copper ions. Its ability to fluoresce in the presence of specific metal ions makes it a valuable tool in chemical research and analytical chemistry for metal ion detection and analysis.
Overall, 3-hydroxy-1,5-naphthyridine-4-carbaldehyde is a versatile compound with a broad spectrum of potential uses in research, pharmaceutical development, and agrochemical synthesis, highlighting its importance in both commercial and scientific domains.

Upstream product

• 1056877-13-4 3-methoxy-1,5-naphthyridine-4-carbaldehyde 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 1045858-10-3 tert-butyl 5-methoxy-4-methylpyridin-3-ylcarbamate 
• 1185094-00-1 3-amino-5-methoxy-4-methylpyridine hydrochloride 
• 893566-31-9 3-methoxy-4-methyl[1,5]naphthyridine 
• 893566-34-2 (3-methoxy[1,5]naphthyridin-4-yl)methyl bromide 
• 1192255-92-7 (3-methoxy[1,5]naphthyridin-4-yl)methanol 
• 64436-92-6 3-amino-5-methoxypyridine 
• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 
• 1056877-12-3 [(E)-2-(3-methoxy-[1,5]-naphthyridin-4-yl)-vinyl]-dimethyl-amine 

Downstream Products

• 1192256-10-2 3-descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl-(1-((3-hydroxy-[1,5]naphthyridin-4-yl)-methyl)-azetidin-3-yl)-imino)-erythromycin A tosylate 

Relevant academic research and scientific papers

Process development of a novel azetidinyl ketolide antibiotic

Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step synthesis features several telescoped operations and direct isolations, which results in a significant improvement in throughput and a major reduction in solvent usage and waste stream volume over the first scale-up campaign. Particular highlights of this effort include the development of an efficient synthesis of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde via a Skraup process and engineering a robust final API synthesis. We also discovered a crystalline monotosylate salt that addressed significant formulation and degradation issues experienced when using the noncrystalline freebase.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safe