1185094-00-1

Basic information

• Product Name: 5-Methoxy-4-methylpyridin-3-amine hydrochloride
• Synonyms: 5-Methoxy-4-methylpyridin-3-amine hydrochloride;3-Pyridinamine, 5-methoxy-4-methyl-, hydrochloride (1:1)
• CAS NO: 1185094-00-1
• Molecular Formula: C₇H₁₀N₂O*ClH
• Molecular Weight: 175
• Mol File: 1185094-00-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5-Methoxy-4-methylpyridin-3-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-4-methylpyridin-3-amine hydrochloride(1185094-00-1)
• EPA Substance Registry System: 5-Methoxy-4-methylpyridin-3-amine hydrochloride(1185094-00-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1185094-00-1(Hazardous Substances Data)

Usage

General Description

5-Methoxy-4-methylpyridin-3-amine hydrochloride is a chemical compound with a molecular formula of C8H12N2OCl. It is a derivative of pyridine and amines and is commonly used in medical and pharmaceutical research. The compound is known for its potential therapeutic properties and is being investigated for its potential use in treating various health conditions including neurological disorders and cancer. It is also used in the synthesis and development of new drugs. Its hydrochloride salt form makes it more stable and soluble in water, which is beneficial for its application in research and development.

Upstream product

• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 
• 64436-92-6 3-amino-5-methoxypyridine 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 1045858-10-3 tert-butyl 5-methoxy-4-methylpyridin-3-ylcarbamate 

Downstream Products

• 77903-28-7 3-Amino-5-methoxy-4-methylpyridine 
• 1192255-92-7 (3-methoxy[1,5]naphthyridin-4-yl)methanol 
• 1056877-13-4 3-methoxy-1,5-naphthyridine-4-carbaldehyde 
• 1056877-14-5 3-hydroxy[1,5]naphthyridine-4-carbaldehyde 
• 1192256-10-2 3-descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl-(1-((3-hydroxy-[1,5]naphthyridin-4-yl)-methyl)-azetidin-3-yl)-imino)-erythromycin A tosylate 

Relevant articles and documents

Process development of a novel azetidinyl ketolide antibiotic

Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step synthesis features several telescoped operations and direct isolations, which results in a significant improvement in throughput and a major reduction in solvent usage and waste stream volume over the first scale-up campaign. Particular highlights of this effort include the development of an efficient synthesis of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde via a Skraup process and engineering a robust final API synthesis. We also discovered a crystalline monotosylate salt that addressed significant formulation and degradation issues experienced when using the noncrystalline freebase.