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Usage

Uses

Used in Pharmaceutical Industry:
2,6-dimethyl-1-phenyl-1H-benzimidazole is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its presence in the molecular structure of certain drugs contributes to their therapeutic properties.
Used in Agrochemical Industry:
2,6-dimethyl-1-phenyl-1H-benzimidazole is used as a chemical intermediate in the production of agrochemicals. Its role in the formulation of these products helps in enhancing their effectiveness in agricultural applications.
Used in Antifungal Applications:
2,6-dimethyl-1-phenyl-1H-benzimidazole is used as an antifungal agent, leveraging its ability to inhibit the growth of fungi, which can be beneficial in various medical and industrial settings.
Used in Antimicrobial Applications:
2,6-dimethyl-1-phenyl-1H-benzimidazole is used as an antimicrobial agent, helping to control the growth of bacteria and other microorganisms, which can be useful in healthcare and sanitation contexts.
Used in Cell Imaging Studies:
2,6-dimethyl-1-phenyl-1H-benzimidazole is used as a fluorescent indicator in cell imaging studies. Its fluorescent properties allow researchers to visualize and track cellular processes, contributing to advancements in cell biology and related fields.

Upstream product

• 591-50-4 iodobenzene 
• 614-83-5 2-bromo-4-methylacetanilide 
• 124-42-5 acetamidine hydrochloride 
• 60956-23-2 3,4-dibromotoluene 
• 14277-00-0 N-phenylacetamidine 
• 71838-16-9 3-bromo-4-iodotoluene 
• 1195791-10-6 C₁₅H₁₅BrN₂ 
• 1195791-10-6 C₁₅H₁₅BrN₂ 

Relevant academic research and scientific papers

Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: Synthesis of benzimidazoles and benzoxazoles

Cobalt(ii)-complex catalyzes efficiently the intramolecular C-N and C-O cross-couplings of Z-N′-(2-halophenyl)-N-phenylamidines and N-(2-bromophenyl)benzamides to afford the corresponding substituted benzimidazoles and benzoxazoles in the presence of K2CO3 at moderate temperature. The protocol is general, air stable and affords the products selectively in moderate to high yield.

Reactivity-controlled regioselectivity: A regiospecific synthesis of 1,2-disubstituted benzimidazoles

We demonstrate exceptional levels of regioselectivity in the tandem, animation reactions between 1,2-differentiated dihaloarenes and N-substituted amidines, The regiochemical outcome of this Cul-catalyzed reaction is achieved through a combination of N1/N2 chemoselectivity on the amidine and reactivity-controlled X1/X2 chemoselectivity on the 1,2-dihaloarene. This reaction proves to be fairly general for the regiospecific synthesis of 1,2-substituted benzimidazoles.

Ligand-free copper-catalyzed synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles

(Chemical Equation Presented) The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. The procedure is experimentally simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. 2009 American Chemical Society.

Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides

(Chemical Equation Presented) We have developed an efficient method for the synthesis of benzimidazoles via cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. The protocol uses 10 mol % CuBr as the catalyst, CS2CO