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10591-84-1

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  • China Northwest Largest Factory Manufacturer Supply BIS(METHYLPHENYLTHIOCARBAMOYL)DISULFIDE/DDTS CAS 10591-84-1

    Cas No: 10591-84-1

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10591-84-1 Usage

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 10591-84-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,9 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10591-84:
(7*1)+(6*0)+(5*5)+(4*9)+(3*1)+(2*8)+(1*4)=91
91 % 10 = 1
So 10591-84-1 is a valid CAS Registry Number.

10591-84-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name [methyl(phenyl)carbamothioyl]sulfanyl N-methyl-N-phenylcarbamodithioate

1.2 Other means of identification

Product number -
Other names bis(N-methyl N-phenyl thiocarbamoyl) disulphide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10591-84-1 SDS

10591-84-1Synthetic route

carbon disulfide
75-15-0

carbon disulfide

N-methylaniline
100-61-8

N-methylaniline

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With N,N-diethylnmethylamine; dihydrogen peroxide In toluene at 0 - 10℃; for 27.5h; Temperature; Reagent/catalyst; Solvent; Large scale;98.9%
With sodium hydroxide at 50℃; for 6h;75%
Stage #1: carbon disulfide; N-methylaniline With potassium hydroxide In tetrahydrofuran; water at 20℃; for 12h;
Stage #2: With iodine In tetrahydrofuran; methanol; water at 20℃; for 1h;
67%
methyl-phenyl-dithiocarbamic acid
37600-51-4

methyl-phenyl-dithiocarbamic acid

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With air; nitrogen oxides in sodaalkolische Loesung;
methyl-phenyl-thiocarbamoyl thiocyanate

methyl-phenyl-thiocarbamoyl thiocyanate

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With sodium sulfide; ethanol und Behandeln der mit Wasser versetzten Reaktionsloesung mit Bromcyan;
N-methylaniline
100-61-8

N-methylaniline

CS2

CS2

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With ethanol; iodine durch Oxydation; oder mit einem anderen Oxydationsmittel;
salt of/the/ methyl-phenyl-dithiocarbamic acid

salt of/the/ methyl-phenyl-dithiocarbamic acid

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With sodium trithionate; ethanol
N-methyl-N-phenylthiocarbamoyl chloride
19009-45-1

N-methyl-N-phenylthiocarbamoyl chloride

sodium salt of a(n) dialkylatedene thiuram disulfide

sodium salt of a(n) dialkylatedene thiuram disulfide

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

N-methylaniline
100-61-8

N-methylaniline

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether
View Scheme
N-methyl-N-phenylthiocarbamoyl chloride
19009-45-1

N-methyl-N-phenylthiocarbamoyl chloride

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol
2: ethanol; sodium sulfide / und Behandeln der mit Wasser versetzten Reaktionsloesung mit Bromcyan
View Scheme
bromocyane
506-68-3

bromocyane

sodium N-methyl-N-phenyldithiocarbamate
39234-21-4

sodium N-methyl-N-phenyldithiocarbamate

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With potassium iodide In water pH:6.2-6.7; in aqueous and non aqueous medium; titration method;
potassium N-methyl-N-phenyl-dithiocarbamate
83559-31-3

potassium N-methyl-N-phenyl-dithiocarbamate

N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In methanol; water at 0 - 5℃;
N,N’-dimethyl-N,N’-diphenylthiuram disulfide
10591-84-1

N,N’-dimethyl-N,N’-diphenylthiuram disulfide

A

carbon disulfide
75-15-0

carbon disulfide

B

N-methylaniline
100-61-8

N-methylaniline

Conditions
ConditionsYield
Beim Erhitzung unter vermindertem Druck;

10591-84-1Relevant articles and documents

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes

Xu, Yi-xiang,Huang, Yun-yuan,Song, Rong-rong,Ren, Yan-liang,Chen, Xin,Zhang, Chao,Mao, Fei,Li, Xiao-kang,Zhu, Jin,Ni, Shuai-shuai,Wan, Jian,Li, Jian

, (2020)

Fructose-1,6-bisphosphatase (FBPase), as a key rate-limiting enzyme in the gluconeogenesis (GNG) pathway, represents a practical therapeutic strategy for type 2 diabetes (T2D). Our previous work first identified cysteine residue 128 (C128) was an important allosteric site in the structure of FBPase, while pharmacologically targeting C128 attenuated the catalytic ability of FBPase. Herein, ten approved cysteine covalent drugs were selected for exploring FBPase inhibitory activities, and the alcohol deterrent disulfiram displayed superior inhibitory efficacy among those drugs. Based on the structure of lead compound disulfiram, 58 disulfide-derived compounds were designed and synthesized for investigating FBPase inhibitory activities. Optimal compound 3a exhibited significant FBPase inhibition and glucose-lowering efficacy in vitro and in vivo. Furthermore, 3a covalently modified the C128 site, and then regulated the N125–S124–S123 allosteric pathway of FBPase in mechanism. In summary, 3a has the potential to be a novel FBPase inhibitor for T2D therapy.

Continuous-flow step-economical synthesis of thiuram disulfidesviavisible-light photocatalytic aerobic oxidation

Xu, Hao-Xing,Zhao, Ze-Run,Patehebieke, Yeersen,Chen, Qian-Qian,Fu, Shun-Guo,Chang, Shuai-Jun,Zhang, Xu-Xu,Zhang, Zhi-Liang,Wang, Xiao

, p. 1280 - 1285 (2021)

A continuous-flow photocatalytic synthesis of the industrially important thiuram disulfides has been developed, utilizing O2as the oxidant and Eosin Y as the photoredox catalyst. This highly atom- and step-economical method features much reduced reaction time as well as excellent product yield and purity, making it a sustainable and potentially scalable process for industrial production.

Thiuram disulfide compound and synthesis process thereof

-

Paragraph 0044-0048, (2019/03/25)

The invention belongs to the field of rubber additives and particularly relates to a thiuram disulfide compound and a synthesis process thereof. The synthesis process comprises the following steps: (1) mixing secondary amine with alkaline liquid, then dropwise adding carbon disulfide, wherein the molar ratio of the secondary amine to the alkaline liquid to the carbon disulfide is 1 to (1-2) to (1-2), and reacting at the temperature of 30-60 DEG C to obtain a sodium dithioformate intermediate; (2) mixing and stirring the sodium dithioformate intermediate obtained in the step (1), dimethylsulfoxide and a dispersant, dropwise adding a strong acid catalyst and reacting at the temperature of 30-80 DEG C, wherein the molar ratio of the sodium dithioformate intermediate to the dimethylsulfoxide to the strong acid catalyst is 2 to (1-1.8) to (2-4), and the molar amount of the catalyst is metered by hydrogen ions; and generating a target product. The product yield of the reaction can reach 95%or above; through HPLC test of the product, the purity can reach up to 96%.

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