37600-51-4Relevant academic research and scientific papers
Synthesis, Crystal Structure, and In Vitro Cytotoxic, Antitumor And Antimicrobial Evaluation of a New Pyrazole Derivative N-3,5-Trimethyl-Nphenyl-1-H-Pyrazole-1-Carbothioamide
Kumar, K. Subin,Priya,Aravindakshan
, p. 1079 - 1086 (2021/01/20)
Anew pyrazole molecule of N-3,5-trimethyl-N-phenyl-1-H-pyrazole-1-carbothioamide (MePhPyC) has been synthesized and characterized by elemental analysis, single crystal x-ray diffraction (XRD), and mass, 1H NMR, ultraviolet-visible (UV-Vis), and
Visible-Light-Induced Photocatalytic Synthesis of β-Keto Dithiocarbamates via Difunctionalization of Styrenes
Vishwakarma, Ramesh Kumar,Kumar, Saurabh,Singh, Krishna Nand
supporting information, p. 4147 - 4151 (2021/05/26)
A facile photocatalyzed strategy for difunctionalization of styrenes in the presence of CS2 and amines providing β-keto dithiocarbamates has been developed. In the case of 4-nitrostyrene and 2-vinylpyridine, however, only 2-arylethylthiocarbamates are interestingly formed without the aid of photoredox catalysis/TBHP.
3 - Methyl -2 - benzothiazolinone hydrazone hydrochloride salt and its hydrate synthesis method
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Paragraph 0016; 0017; 0018, (2019/01/08)
The present invention provides 3 - methyl - 2 - benzothiazolinone hydrazone hydrochloride salt and its hydrate synthesis method, which belongs to the field of organic synthesis. N - methylaniline with carbon disulfide reaction to obtain N - methyl - N - phenyl dithio-, then reaction with bromine 3 - methylbenzothiazol - 2 - thione, then reacting with hydrazine hydrate to produce 3 - methyl - 2 - benzothiazolinone hydrazone, subsequently react with hydrochloric acid to obtain 3 - methyl - 2 - benzothiazolinone hydrazone hydrochloride, recrystallization to obtain water in 3 - methyl - 2 - benzothiazolinone hydrazone hydrochloride hydrate. In the present invention the used raw materials are cheap and easily obtained, the operation process is simple, and has potential industrial amplifying application prospect.
Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates
Zou, Yan,Yu, Shichong,Li, Renwu,Zhao, Qingjie,Li, Xiang,Wu, Maocheng,Huang, Ting,Chai, Xiaoxun,Hu, Honggang,Wu, Qiuye
, p. 366 - 374 (2014/02/14)
A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl) propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a-f and 3a-q exhibited higher activities than fluconazole against nearly all fungi tested except Aspergillus fumigatus. Noticeably, the in vitro biological activities of 2b, 3a, 3c, 3h-k, and 3o-q against Candida species were much better than those of fluconazole and ketoconazole. Also, 2a-d, 3a-d, 3e-f, 3h-k, 3p and 3q showed higher activities against A. fumi than fluconazole. Computational docking experiments indicated that the inhibition of CYP51 involved a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft.
Facile one pot synthesis of a range of reversible addition-fragmentation chain transfer (RAFT) agents
Skey, Jared,O'Reilly, Rachel K.
supporting information; experimental part, p. 4183 - 4185 (2009/03/11)
The application of a universal synthetic strategy for the high yielding and facile synthesis of a wide range of functional RAFT agents including trithiocarbonates, xanthates and dithiocarbamates is described. The Royal Society of Chemistry.
