105962-57-0

Basic information

• Product Name: (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE
• Synonyms: (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE;2-Propenoic acid, 2-(acetylaMino)-3-(4-nitrophenyl)-, Methyl ester, (2Z)-
• CAS NO: 105962-57-0
• Molecular Formula: C₁₂H₁₂N₂O₅
• Molecular Weight: 264.23408
• Mol File: 105962-57-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE(105962-57-0)
• EPA Substance Registry System: (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE(105962-57-0)

Safety Data

• Hazardous Substances Data: 105962-57-0(Hazardous Substances Data)

Usage

General Description

(Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE is a chemical compound with the molecular formula C13H12N2O5. It is a yellow solid with a molecular weight of 276.25 g/mol. (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE is used in organic synthesis and as a pharmaceutical intermediate. It is also used in the production of certain drugs and as a building block for other chemical compounds. (Z)-METHYL 2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLATE has potential use in the development of new pharmaceuticals and may also have other industrial applications. However, it is important to handle and use this compound with care, as it may have potential health and environmental hazards.

Upstream product

• 67-56-1 methanol 
• 555-16-8 4-nitrobenzaldehdye 
• 543-24-8 N-acetylglycine 
• 66949-13-1 (Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one 
• 124-41-4 sodium methylate 
• 35356-70-8 Methyl 2-acetamidoacrylate 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 105962-36-5 methyl Z-2-acetamido-3-p-nitrophenyl-2-butanoate 
• 21742-96-1 4-(4-nitro-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 111016-50-3 4-(4-Nitro-phenyl)-1H-pyrazole-3-carboxylic acid 
• 36097-39-9 (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 88546-12-7 methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate 
• 105962-48-9 cis-4-p-nitrophenyl-3-acetamido-3-carbomethoxy-Δ¹-pyrazoline 

Relevant articles and documents

Ni(ii)-Catalyzed vinylic C-H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

A ligand-free Ni(ii)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylatesviavinylic C-H functionalization is reported. The reaction proceeds through heteroatom guided electrophilic insertion of nickel to the vinylic double bond followed by annulation with dibromomethane. This unconventional route features cascade steps, sole product formation, multiple functional group tolerance, low cost of catalysts and reagents, and readily available starting materials. Using this method, various aryl-substituted isotetronic acids have been synthesized which are biologically relevant. The annulation of 2-acetamido-3-arylacrylates has also been assessed with 1,2-dichloroethane, which resulted in the rearranged annulated products of 5-methyl substituted isotetronic acids.

Temperature-controlled bidirectional enantioselectivity in a dynamic catalyst for asymmetric hydrogenation

Asymmetric catalysis using enantiomerically pure catalysts is one of the most widely used methods for the preparation of enantiomerically pure compounds. The separate synthesis of both enantiomerically pure compounds requires tedious and time-consuming pr

Palladium-Catalyzed Synthesis of Didehydroamino Acid Derivatives

The palladium-catalyzed coupling of 2-amidoacrylates with aryl iodides under phase-transfer conditions yields aromatic (Z)-didehydroamino acid derivatives, which give various protected aromatic amino acids via catalytic hydrogenation using Pd/C or the Wil