182810-28-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 182810-26-0 C₂₇H₃₀ClN₄O₁₁P 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 131118-61-1 3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 
• 105972-87-0 di(2-chlorophenyl) chloromethylphosphonate 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 149741-60-6 {(E)-2-[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-vinyl}-phosphonic acid bis-(2-chloro-phenyl) ester 
• 149741-59-3 Bis(o-chlorophenyl) (triphenylphosphoranylidenemethyl)phosphonate 

Relevant academic research and scientific papers

Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides

Thymidine deoxyoligonucleotides having a 5'-deoxy-5'-methylidyne phosphonate internucleotide linkage were synthesized. Relative to natural DNA, these oligomers were nuclease resistant and formed duplexes with reduced stability.