105973-37-3

Basic information

• Product Name: 2-(cyclohexyloxy)aniline
• Synonyms: 2-(cyclohexyloxy)aniline;2-Cyclohexyloxy-phenylamine hydrochloride
• CAS NO: 105973-37-3
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 105973-37-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 55-56 °C
• Boiling Point: 318.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.073±0.06 g/cm3(Predicted)
• PKA: 4.45±0.10(Predicted)
• CAS DataBase Reference: 2-(cyclohexyloxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyclohexyloxy)aniline(105973-37-3)
• EPA Substance Registry System: 2-(cyclohexyloxy)aniline(105973-37-3)

Safety Data

• Hazardous Substances Data: 105973-37-3(Hazardous Substances Data)

Usage

General Description

2-(cyclohexyloxy)aniline is a chemical compound that belongs to the class of aromatic amines. It is also known by its IUPAC name, 1-amino-2-(cyclohexyloxy)benzene. 2-(cyclohexyloxy)aniline consists of a benzene ring with an amino group attached at the 1-position and a cyclohexyl group attached through an oxygen atom at the 2-position. It is commonly used as an intermediate in the synthesis of various organic compounds, including dyes, pharmaceuticals, and polymers. The chemical properties and reactivity of 2-(cyclohexyloxy)aniline make it a versatile building block for the production of a wide range of commercial products. However, it is important to handle this compound with care, as it can be hazardous if not properly handled and managed.

Upstream product

• 108-93-0 cyclohexanol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 30718-74-2 2-cyclohexyloxynitrobenzene 

Downstream Products

• 1323064-60-3 C₄₅H₃₅NO₄ 
• 627098-50-4 2-cyclohexyloxy-N-cyclohexylaniline 
• 101450-31-1 N_.N-Bis-(2-hydroxyaethyl)-2-cyclohexyloxy-anilin 

Relevant articles and documents

A molecular balance for measuring aliphatic CH-π interactions

A series of conformationally flexible bicyclic N-arylimides were employed as molecular balances to study the weak aliphatic CH-π interaction between alkyl and arene groups. The formation of intramolecular CH-π interactions in the folded conformers was characterized by X-ray crystallography. The strengths of the interactions were characterized in CDCl3 by the changes in the folded/unfolded ratios, as measured by 1H NMR. The CH-π interaction between a methyl group and an aromatic surface was ～1.0 kcal/mol and was easily disrupted or masked by conformational entropy and repulsive steric interactions.

THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

Derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II STR1