28721-30-4

Upstream product

• 3810-10-4 2-amino-3-benzoylpyridine 
• 57-13-6 urea 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 79-22-1 methyl chloroformate 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 86847-67-8 N-<3-(Hydroxyphenylmethyl)-2-pyridinyl>-2,2-dimethylpropanamide 
• 125867-32-5 phenyl (2-pivaloylamino-3-pyridyl) ketone 
• 86847-59-8 2-(pivaloylamino)pyridine 

Downstream Products

• 1059735-38-4 2-chloro-4-phenylpyrido[2,3-d]pyrimidine 

Relevant academic research and scientific papers

INHIBITORS OF THE HEDGEHOG PATHWAY

The present invention is directed to a compound of Formula (I) or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula (I) to treat cancer.

Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives

The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.