1381870-57-0

Basic information

• Product Name: 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine
• Synonyms: 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine
• CAS NO: 1381870-57-0
• Molecular Weight: 313.359
• Mol File: 1381870-57-0.mol

Chemical Properties

• CAS DataBase Reference: 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine(1381870-57-0)
• EPA Substance Registry System: 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine(1381870-57-0)

Safety Data

• Hazardous Substances Data: 1381870-57-0(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 5720-07-0 4-methoxyphenylboronic acid 
• 126728-20-9 2,4-dichloropyrido[2,3-d]pyrimidine 
• 1059735-38-4 2-chloro-4-phenylpyrido[2,3-d]pyrimidine 

Relevant articles and documents

UV Light-mediated regioselective methylsulfanyl discrimination via Pd-catalyzed cross-coupling reactions of 2,4-dimethylsulfanylpyrido[2,3-d]pyrimidines

An effective and novel photochemical method for the preparation of 2,4-disubstituted pyrido[2,3-d]pyrimidines is reported from 2,4-dimethylsulfanyl-pyrido[2,3-d]pyrimidines through a Liebeskind-Sroglcoupling reaction involving an original selective methyl sulfanyl discrimination using UV light as a source of energy. Our strategies involve a two-step and a one-pot approach with reaction times of 11-18 h and yields ranging between 72 and 94%. The two strategies are compared.

Convenient synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines via regioselective palladium-catalyzed reactions

A novel and effective route for the synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines III is reported starting from the corresponding 2,4-dichloropyridopyrimidine 1 through regioselective functionalization palladium-catalyzed C-C coupling reactions, by two successive palladium-catalyzed reactions involving an original regioselective chlorine discrimination. Alternatively, type III compounds were elaborated from 2 by C-2 chlorine further displacement of the C-4 isopropylsulfanyl group, which acted as a temporary C-4 protecting group. Further Suzuki-Miyaura cross-coupling reactions led to C-2 and C-4 disubstituted compounds.