105986-58-1Relevant articles and documents
Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides
Andrei, Daniela,Wnuk, Stanislaw F.
, p. 405 - 408 (2007/10/03)
The 1-fluoro-1-haloalkenes undergo Pd-catalyzed Negishi cross-couplings with primary alkylzinc bromides to give multisubstituted fluoroalkenes. The alkylation was trans-selective giving pure Z-fluoroalkenes in most cases. The highest yields were obtained with Pd2(dba)3 and PdCl 2(dppb) catalysts but the best stereochemical outcome was obtained with less reactive Pd(PPh3)4. The tertiary alkylzincs also produced desired fluoroalkenes in high yields. Coupling of β,β- dichlorostyrene with organozinc reagent resulted in the formation of monocoupled product.
Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships
Konno, Mitoshi,Nakae, Takahiko,Sakuyama, Shigeru,Odagaki, Yoshihiko,Nakai, Hisao,Hamanaka, Nobuyuki
, p. 1649 - 1674 (2007/10/03)
A series of trisubstituted benzenes which demonstrate leukotriene B4 (LTB4, 1) receptor affinity was prepared. Previous trisubstituted benzenes from our laboratory showed high affinity to the LTB4 receptor but demonstrated
ALKYL-ALKENYL CROSS COUPLING VIA ALKYL COBALOXIME RADICAL CHEMISTRY. AN ALKYL EQUIVALENT TO THE HECK REACTION COMPATIBLE WITH COMMON ORGANIC FUNCTIONAL GROUPS
Branchaud, Bruce P.,Meier, Mark S.,Choi, Youngshin
, p. 167 - 170 (2007/10/02)
A novel cobalt-mediated radical-olefin coupling reaction is described which regenerates the olefin functionality in the final product.The regeneration of olefin functionality is unique among radical-olefin couplings using simple activated alkenes.
ARYLATION AND VINYLATION OF 2-CARBOETHOXYETHYLZINC IODIDE AND 3-CARBOETHOXYPROPYLZINC IODIDE CATALYZED BY PALLADIUM
Tamaru, Y.,Ochiai, H.,Nakamura, T.,Yoshida, Z.
, p. 955 - 958 (2007/10/02)
By the palladium catalysis 2-carboethoxyethylzinc iodide reacts with aryl iodides and vinyl iodides or triflates to provide the coupling products (ethyl 3-arylpropionates and ethyl 4-pentenoates, respectively) in satisfactory yields.The similar coupling reaction is observed for the reaction with 3-carboethoxypropylzinc iodide.
