106014-95-3

Basic information

• Product Name: 3-Azetidinecarboxylic acid, 3-(hydroxymethyl)-1-(phenylmethyl)-
• CAS NO: 106014-95-3
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 106014-95-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Azetidinecarboxylic acid, 3-(hydroxymethyl)-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azetidinecarboxylic acid, 3-(hydroxymethyl)-1-(phenylmethyl)-(106014-95-3)
• EPA Substance Registry System: 3-Azetidinecarboxylic acid, 3-(hydroxymethyl)-1-(phenylmethyl)-(106014-95-3)

Safety Data

• Hazardous Substances Data: 106014-95-3(Hazardous Substances Data)

Upstream product

• 137606-01-0 N-benzyl-3-chloro-2,2-bis(chloromethyl)propanamide 
• 137266-59-2 1-benzyl-3,3-bis(chloromethyl)azetidin-2-one 
• 50547-79-0 3-chloro-2,2-dipropionyl chloride 
• 17831-70-8 3-chloro-2,2-bis(chloromethyl)propionic acid-1 
• 137266-85-4 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester 

Downstream Products

• 26096-30-0 N-benzyl-3,3-bis-(hydroxymethyl)-azetidine 

Relevant articles and documents

Concise synthesis of novel 2,6-diazaspiro[3.3]heptan-1-ones and their conversion into 2,6-diazaspiro[3.3]heptanes

A concise synthesis, amenable to library production of 2,6-diazaspiro[3.3] heptan-1-ones and their subsequent conversion into 2,6-diazaspiro[3.3]heptanes is reported. Georg Thieme Verlag Stuttgart.

Process for preparing azetidine derivatives; and intermediates therein

Process for the preparation of a compound of formula or a salt thereof STR1 wherein R1 represents a hydrogen atom or a group of formula R2 SO2 or phenyl--CH(R3)--wherein R2 represents a phenyl, tolyl or C1-4 alkyl group and R3 represents a hydrogen atom or a phenyl of C1-4 alkyl group, which process comprises contacting nickel in an oxidation state of at least 3 with a 3-hydroxymethyl azetidine derivative of formula STR2 wherein R4 represents a group of formula R2 SO2 or phenyl--CH(R3)--and R5 represents a hydrogen atom or a hydroxymethyl group or a group of formula COOH or a salt thereof, followed, where R5 is not a hydrogen atom, by the decarboxylation of the compound of the 3,3-dicarboxylic intermediate product or a salt thereof and, if desired to produce a compound in which R1 represents a hydrogen atom, by deprotection of the N-atom. Also, novel N-substituted azetidine carboxylate derivatives of the formula STR3 wherein X represents a group CH2 OH or COOY where Y represents a hydrogen or an alkali or alkaline earth metal atom.