106086-10-6

Basic information

• Product Name: 3-(tert-Butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid
• Synonyms: 3-(tert-Butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid;N-Boc-2-phenylthiazolidine-4-carboxylic acid
• CAS NO: 106086-10-6
• Molecular Weight: 309.386
• Mol File: 106086-10-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-(tert-Butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-Butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid(106086-10-6)
• EPA Substance Registry System: 3-(tert-Butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid(106086-10-6)

Safety Data

• Hazardous Substances Data: 106086-10-6(Hazardous Substances Data)

Upstream product

• 196930-46-8 (4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 52-89-1 l-cysteine hydrochloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 161458-78-2 (2R,4R)-4-(hydroxymethyl)-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester 
• 1208224-22-9 tert-butyl-(4R)-4-formyl-2-phenylthiazolidine-3-carboxylate 
• 106086-24-2 Methyl N,N'-α,ε-bis(2-phenylthiazolidine-4-carbonyl)-L-lysine bis-hydrochloride 
• 106086-18-4 Methyl N,N'-α,ε-bis(N-tert-butyloxycarbonyl-2-phenylthiazolidine-4-carbonyl)-L-lysine 
• 106086-23-1 Methyl 2-phenylthiazolidine-4-carbonyl-N-γ-aminobutyrate hydrochloride 
• 106086-22-0 2-Phenylthiazolidine-4-carboxylic acid hexylamide hydrochloride 
• 106086-25-3 β-Mercaptoethylamide-2-phenylthiazolidine-4-carboxylic acid hydrochloride 
• 106086-21-9 2-Phenylthiazolidine-4-carboxylic acid hydrazide hydrochloride 
• 106086-20-8 2-Phenylthiazolidine-4-carboxylic acid amide hydrochloride 
• 106086-17-3 Methyl N-tert-butyloxycarbonyl-2-phenylthiazolidine-4-carbonyl-N'-γ-aminomethyl butyrate 
• 106086-16-2 N-tert-Butyloxycarbonyl-2-phenylthiazolidine-4-carboxylic acid hexylamide 
• 106086-19-5 N-tert-Butyloxycarbonyl-2-phenylthiazolidine-4-carboxylic acid β-mercaptoethylamide 
• 106086-15-1 N-tert-Butyloxycarbonyl-2-phenylthiazolidine-4-carboxylic acid hydrazide 
• 106086-14-0 N-tert-Butyloxycarbonyl-2-phenylthiazolidine-4-carboxylic acid amide 

Relevant articles and documents

Stereoselective synthesis of chiral thiol-containing 1,2-aminoalcohols via SmI2-mediated coupling

The stereoselective synthesis of highly functionalized aminohydroxythiols represents a synthetic challenge as the oxidation sensitivity and coordinating property of the thiol group interferes with many established synthetic methods. The SmI2/Li

Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents

A series of (2RS,4R)-2-arylthiazolidine-4-carboxylic acid amide (ATCAA) was synthesized. Antiproliferative activity against melanoma and prostate cancer cells compared with control cells (fibroblast and RH7777, respectively) was evaluated. Compound 3id sh

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: Synthesis, biological evaluation, and structure-activity relationships

A series of 4-substituted methoxybenzoyl-aryl-thiazoles (SMART) have been discovered and synthesized as a result of structural modifications of the lead compound 2-arylthiazolidine-4-carboxylic acid amides (ATCAA). The antiproliferative activity of the SMART agents against melanoma and prostate cancer cells was improved from μM to low nM range compared with the ATCAA series. The structure-activity relationship was discussed from modifications of "A", "B", and "C" rings and the linker. Preliminary mechanism of action studies indicated that these compounds exert their anticancer activity through inhibition of tubulin polymerization.