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106331-71-9

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106331-71-9 Usage

Description

2,3-dibromo-5,6-dimethoxypyridine is a pyridine derivative with the molecular formula C7H6Br2N2O2, featuring two bromine atoms and two methoxy groups attached to the aromatic ring. This chemical compound is known for its versatility in organic synthesis and its applications in the pharmaceutical industry.

Uses

Used in Organic Synthesis:
2,3-dibromo-5,6-dimethoxypyridine is used as a reagent in various organic reactions, such as Suzuki-Miyaura cross-coupling and Sonogashira coupling reactions. Its presence in these reactions facilitates the formation of new carbon-carbon and carbon-heteroatom bonds, contributing to the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-dibromo-5,6-dimethoxypyridine serves as an intermediate in the synthesis of potential drug candidates. Its unique structure and functional groups make it a valuable building block for the development of new therapeutic agents.
Used in Medicinal Chemistry:
2,3-dibromo-5,6-dimethoxypyridine is utilized in medicinal chemistry for the preparation of bioactive compounds. Its structural features allow for the design and synthesis of molecules with potential therapeutic properties, contributing to the discovery of new drugs.
Used in Material Science:
2,3-dibromo-5,6-dimethoxypyridine also finds applications in material science, where it can be incorporated into the development of novel materials with specific properties. Its versatility and reactivity make it a promising candidate for creating advanced materials with applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 106331-71-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,3,3 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 106331-71:
(8*1)+(7*0)+(6*6)+(5*3)+(4*3)+(3*1)+(2*7)+(1*1)=89
89 % 10 = 9
So 106331-71-9 is a valid CAS Registry Number.

106331-71-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dibromo-2,3-dimethoxypyridine

1.2 Other means of identification

Product number -
Other names 2,3-dibromo-5,6-dimethoxypyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106331-71-9 SDS

106331-71-9Relevant articles and documents

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease

Sagong, Hye Yeon,Bauman, Joseph D.,Nogales, Aitor,Martínez-Sobrido, Luis,Arnold, Eddy,LaVoie, Edmond J.

, p. 1204 - 1223 (2019)

Seasonal influenza infections are associated with an estimated 250–500 000 deaths annually. Resistance to the antiviral M2 ion-channel inhibitors has largely invalidated their clinical utility. Resistance to neuraminidase inhibitors has also been observed in several influenza A virus (IAV) strains. These data have prompted research on inhibitors that target the cap-snatching endonuclease activity of the polymerase acidic protein (PA). Baloxavir marboxil (Xofluza), recently approved for clinical use, inhibits cap-snatching endonuclease. Resistance to Xofluza has been reported in both in vitro systems and in the clinic. An X-ray crystallographic screening campaign of a fragment library targeting IAV endonuclease identified 5-chloro-3-hydroxypyridin-2(1H)-one as a bimetal chelating agent at the active site. We have reported the structure–activity relationships for 3-hydroxypyridin-2(1H)-ones and 3-hydroxyquinolin-2(1H)-ones as endonuclease inhibitors. These studies identified two distinct binding modes associated with inhibition of this enzyme that are influenced by the presence of substituents at the 5- and 6-positions of 3-hydroxypyridin-2(1H)-ones. Herein we report the structure–activity relationships associated with various para-substituted 5-phenyl derivatives of 6-(p-fluorophenyl)-3-hydroxypyridin-2(1H)-ones and the effect of using naphthyl, benzyl, and naphthylmethyl groups as alternatives to the p-fluorophenyl substituent on their activity as endonuclease inhibitors.

Synthetic method of 2,5,6-trimethoxy-3-picolinic acid

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, (2017/11/04)

The invention relates to a synthetic method of 2,5,6-trimethoxy-3-picolinic acid, which mainly solves the technical problem that no effective synthetic methods are provided at present. The synthetic method provided by the invention comprises the following steps: converting 2-chloro-3-hydroxypyridine hydroxy into methoxy; carrying out methoxy nucleophilic substitution of chlorine; carrying out bromination of a pyridine ring; and carrying out methoxy selective substitution of bromine; removing bromine from n-butyllithium, reacting with carbon dioxide, and introducing carboxy so as to obtain 2,5,6-trimethoxy-3-picolinic acid. In the whole synthetic process, intermediates and object products do not need to be separated through a chromatographic column, the raw materials are cheap, and the purification is simple.

THERAPEUTIC HYDROXYPYRIDINONES, HYDROXYPYRIMIDINONES AND HYDROXYPYRIDAZINONES

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Page/Page column 49, (2014/04/03)

The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

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