106419-92-5

Upstream product

• 103633-30-3 2-bromomethylphenyl benzyl ether 
• 100-39-0 benzyl bromide 
• 90-01-7 salicylic alcohol 
• 106419-88-9 diethyl 2-(2-(benzyloxy)benzyl)malonate 
• 23915-08-4 2-benzyloxybenzyl chloride 
• 3381-87-1 2-benzyloxybenzyl alcohol 

Downstream Products

• 881672-51-1 2,2-dimethyl-propionic acid 2-hydroxymethyl-3-(2-hydroxy-phenyl)-propyl ester 
• 881672-57-7 2,2-dimethyl-propionic acid 3-(2-benzyloxy-phenyl)-2-hydroxymethyl-propyl ester 

Relevant academic research and scientific papers

An aryne triggered ring-opening fluorination of cyclic thioethers with potassium fluoride

Herein, we report an aryne triggered ring-opening fluorination protocol of a great variety of saturated sulfur heterocycles. A key factor for the success is the identification of a suitable mediator. Compared to previous methods, this transition-metal free protocol employs low-cost potassium fluoride as the fluorine source. The operational simplicity and mild reaction conditions allow for the rapid synthesis of a wide range of aliphatic fluoride compounds in good yields.

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.