23915-08-4

Usage

Uses

Used in Organic Synthesis:
2-(Benzyloxy)benzyl chloride is used as a reagent for the formation of various organic compounds and pharmaceutical intermediates. Its unique structure allows it to participate in a wide range of chemical reactions, contributing to the synthesis of complex molecules and advancing the development of new pharmaceuticals and chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Benzyloxy)benzyl chloride is used as a starting material for the production of diverse chemical compounds. Its versatility and reactivity make it an essential component in the synthesis of various drugs and therapeutic agents, facilitating the discovery and development of novel medications to address a wide array of health conditions.
Used in Chemical Compound Production:
2-(Benzyloxy)benzyl chloride is also utilized as a starting material in the production of a variety of chemical compounds. Its ability to undergo multiple chemical transformations makes it a valuable precursor in the synthesis of specialty chemicals, agrochemicals, and other industrial products, further highlighting its importance in the realm of organic chemistry.

Upstream product

• 100-39-0 benzyl bromide 
• 89-95-2 2-methyl-benzyl alcohol 
• 611-20-1 salicylonitrile 
• 14389-86-7 2-benzyloxybenzoic acid 
• 74511-44-7 o-(benzyloxy)benzonitrile 
• 90-01-7 salicylic alcohol 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 

Downstream Products

• 152832-47-8 1-Benzyloxy-2-phenylsulfanylmethyl-benzene 
• 86933-22-4 1-(2-benzyloxybenzyl)cycloheptanol 
• 178160-21-9 1-(2-Benzyloxybenzyl)-5-nitro-1H-indazol-3-ol 
• 170292-40-7 2-(2-benzyloxybenzyl)-1-cyclohexylethane-1-ol 
• 92552-22-2 (2-benzyloxyphenyl)acetonitrile 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 881672-54-4 2,2-dimethyl-propionic acid 3-hydroxy-2-(2-hydroxy-phenyl)-propyl ester 
• 881672-73-7 2-[2-(benzyloxy)phenyl]-1,3-propanediol 
• 881672-51-1 2,2-dimethyl-propionic acid 2-hydroxymethyl-3-(2-hydroxy-phenyl)-propyl ester 
• 106419-92-5 2-[2-(benzyloxy)benzyl]-1,3-propanediol 
• 881672-71-5 dimethyl 2-[2-(benzyloxy)benzyl]malonate 
• 881672-60-2 2,2-dimethyl-propionic acid 2-(2-benzyloxy-phenyl)-3-hydroxy-propyl ester 
• 881672-57-7 2,2-dimethyl-propionic acid 3-(2-benzyloxy-phenyl)-2-hydroxymethyl-propyl ester 
• 22047-88-7 2-hydroxyphenylacetic acid benzyl ether 

Relevant academic research and scientific papers

High diastereoselectivity in the yang photocyclization via remote hydrogen abstraction reaction

1-Benzoyl-1-(o-alkoxyphenyl)cyclopropanes undergo Yang photocyclization to form dihydrobenzopyranols in a stereospecific manner. The cyclopropyl group at alpha position to carbonyls gives not only a bias in the most stable geometries of the starting ketones but also conformational restriction on geometries of biradical intermediates. More importantly, intramolecular hydrogen bonds seem to give an additional effect on conformational control of the biradical reactivity.

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.

Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxypyridin-4-ones, novel iron chelators

Novel 3-hydroxypyridin-4-one containing tridentate ligands were synthesised and their physicochemical properties characterised, including ionisation constants and stoichiometric titration with Fe(III). There is an urgent demand for orally active iron chelators with potential for the treatment of thalassaemia. In principle, tridentate ligands are likely to be more kinetically stable than bidentate molecules, but to date no satisfactory molecules have been identified. Fe(III) stability constants were assessed by competition with the hexadentate ligand EDTA. In all cases no evidence was found for a tridentate mode of iron chelation; instead the ligands behaved as bidentate hydroxypyridinones. As a consequence they provide no advantage over the more simple alkyl hydroxypyridinones.

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.