106429-67-8

Usage

Uses

Used in Aerospace and Automotive Industries:
(1H-Benzo[d][1,2,3]triazol-5-yl)methanol is used as a corrosion inhibitor for metals, providing protection against corrosion and enhancing the longevity of metal components in aerospace and automotive applications.
Used in Pharmaceutical Synthesis:
As an intermediate in the synthesis of pharmaceuticals, (1H-Benzo[d][1,2,3]triazol-5-yl)methanol contributes to the development of new drugs and medicines, leveraging its unique chemical properties to create innovative therapeutic agents.
Used in Dye and Organic Compound Synthesis:
(1H-Benzo[d][1,2,3]triazol-5-yl)methanol is utilized as an intermediate in the synthesis of dyes and other organic compounds, enabling the creation of a wide range of products with diverse applications.
Used in Polymer Stabilization:
(1H-BENZO[D][1,2,3]TRIAZOL-5-YL)METHANOL is used as a stabilizer for polymers, enhancing their resistance to degradation and improving their overall performance in various applications.
Used as a UV-Absorber in Plastics:
(1H-Benzo[d][1,2,3]triazol-5-yl)methanol is employed as a UV-absorber in plastics, protecting the material from the damaging effects of ultraviolet radiation and extending its service life.
Used in Anti-Inflammatory and Anti-Cancer Research:
(1H-Benzo[d][1,2,3]triazol-5-yl)methanol has been studied for its potential anti-inflammatory and anti-cancer properties, indicating its potential as a therapeutic agent in the medical field.

InChI:InChI=1/C7H7N3O/c11-4-5-1-2-6-7(3-5)9-10-8-6/h1-3,11H,4H2,(H,8,9,10)

Upstream product

• 23814-12-2 1h-benzotriazole-5-carboxylic acid 
• 491612-10-3 C₈H₇N₃O₂ 
• 1246639-99-5 C₁₀H₁₁N₃O₂ 
• 136-85-6 5⁽⁶⁾-methylbenzotriazole 
• 442911-05-9 tert-butyl 5-methylbenzotriazole-1-carboxylate 
• 113053-50-2 1H-Benzotriazole-5-carboxylic acid methyl ester 
• 73605-91-1 1H-benzotriazole-5-carboxylic acid ethyl ester 

Downstream Products

• 70938-42-0 1H-1,2,3-benzotriazole-5-carbaldehyde 

Relevant academic research and scientific papers

Synthesis and practical use of 1H-1,2,3-benzotriazole-5-carboxaldehyde for reductive amination

A reliable synthetic procedure to obtain multigram quantities of 1H-1,2,3-benzotriazole-5-carboxaldehyde has been developed. This material can be used in reductive amination reactions with primary and secondary amines to provide good to excellent yields o

Passivation solution Treated copper foil and lithium battery packaging film comprising same

The invention relates to a methyl benzotriazole derivative passivator, passivating liquid containing the passivator, a copper foil treated by the passivating liquid, and a lithium battery packaging film containing the copper foil. The structure of a methyl benzotriazole derivative is shown in a formula (I). The copper foil passivated by treatment liquid containing the passivator has strong adhesive force with a polyolefin adhesive and a polyurethane adhesive, and when the copper foil is applied to the lithium battery packaging film, and the obtained lithium battery packaging film is stable instructure and has long service life, excellent stamping performance and electrolyte resistance.

Imidazolium-supported benzotriazole: an efficient and recoverable activating reagent for amide, ester and thioester bond formation in water

An efficient and recyclable imidazolium-supported benzotriazole reagent (Im-CH2-BtH) as a novel synthetic auxiliary has been synthesized and its utility as a carboxyl group activating reagent via the formation of stable imidazolium-supported acyl benzotriazoles was explored for the synthesis of amides, esters and thioesters in water under microwave conditions. The reagent was reused five times without any noticeable loss in activity. It is moisture insensitive and highly stable under thermal and aerobic conditions. The application of imidazolium-supported N-acetyl benzotriazole leads to synthesis of paracetamol on the gram scale under greener conditions in 93% yield.

Substituted Pyran Derivatives

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter system

INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLMONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER

The present invention is directed to a compound is represented by Structural Formula (A):or a pharmaceutically acceptable salt therof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.

Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents

Recently, 1,3-diarylalkyl thioureas have merged as one of the promising nonvanilloid TRPV1 antagonists possessing excellent therapeutic potential in pain regulation. In this paper, the full structure-activity relationship for TRPV1 antagonism of a novel series of 1,3-diarylalky thioureas is reported. Exploration of the structure-activity relationship, by systemically modulating three essential pharmacophoric regions, led to six examples of 1,3-dibenzyl thioureas, which exhibit Ca2+ uptake inhibition in rat DRG neuron with IC50 between 10 and 100 nM.