113053-50-2

Usage

Chemical Properties

orange to brown powder

InChI:InChI=1/C8H7N3O2/c1-13-8(12)5-2-3-6-7(4-5)10-11-9-6/h2-4H,1H3,(H,9,10,11)

Upstream product

• 67-56-1 methanol 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 3987-92-6 methyl 4-amino-3-nitrobenzoate 
• 1588-83-6 4-amino-3-nitrobenzoic acid 
• 23814-12-2 1h-benzotriazole-5-carboxylic acid 

Downstream Products

• 67-56-1 methanol 
• 23814-12-2 1h-benzotriazole-5-carboxylic acid 
• 132680-56-9 methyl 6,7-epoxy-6,7-dihydro-1H-benzotriazole-5-carboxylate 
• 70938-42-0 1H-1,2,3-benzotriazole-5-carbaldehyde 
• 1158624-03-3 C₂₅H₃₃N₃O₄ 
• 1158624-05-5 C₂₅H₃₃N₃O₄ 
• 1158624-08-8 C₂₅H₃₁N₃O₄ 
• 1158624-10-2 C₂₅H₃₁N₃O₄ 
• 73605-91-1 1H-benzotriazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR

Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1’-position and 5’-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.