106439-47-8Relevant articles and documents
Preparation method of 3-hydroxy-6-ketocholanic acid with low cost and high yield
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Paragraph 0036-0041, (2020/06/20)
The invention discloses a preparation method of 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid with low cost and high yield, which is characterized by comprising the following steps: adding hyodeoxycholic acid into a mixed solution of an organic solvent and water, and stirring to dissolve; adding bromide and acid, stirring and dissolving; bromate is added for reaction; adding a terminating agent, and stirring to terminate the reaction; adding water to crystallize the product; and carrying out solid-liquid separation, washing a solid product with water for multiple times, and drying to obtainthe 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid. According to the method, a common and safe reagent is adopted, the hyodeoxycholic acid is selectively oxidized into the 3 alpha-hydroxy-6-keto-5beta-cholestane-24-acid under a relatively mild condition, the product purity is greater than 98.0%, and the yield is greater than 85%. The method has the advantages of cheap reagents, simple operation, high process reproducibility, simple post-treatment, high product purity and high yield, and can easily implement industrial production.
Method for synthesizing lithocholic acid from hyodesoxycholic acid
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Paragraph 0036; 0037; 0038; 0039, (2017/08/29)
The invention discloses a method for synthesizing lithocholic acid, comprising: using hyodesoxycholic acid as a start material, and performing two-step reaction of 6Alpha-OH selective oxidation and Huang Minglon reduction to synthesize the lithocholic acid. The start material herein is low in price and easy to obtain, the synthetic steps are short, posttreatment is simple, few side reactions are employed, and the method is applicable to industrial production.
