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CAS

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1065179-27-2

3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1065179-27-2 Structure

  • Basic information

    1. Product Name: 3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide
    2. Synonyms:
    3. CAS NO:1065179-27-2
    4. Molecular Formula:
    5. Molecular Weight: 354.43
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1065179-27-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide(1065179-27-2)
    11. EPA Substance Registry System: 3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide(1065179-27-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1065179-27-2(Hazardous Substances Data)

1065179-27-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1065179-27-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,5,1,7 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1065179-27:
(9*1)+(8*0)+(7*6)+(6*5)+(5*1)+(4*7)+(3*9)+(2*2)+(1*7)=152
152 % 10 = 2
So 1065179-27-2 is a valid CAS Registry Number.

1065179-27-2Downstream Products

1065179-27-2Relevant articles and documents

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

Kerns, Jeffrey K.,Busch-Petersen, Jakob,Fu, Wei,Boehm, Jeffrey C.,Nie, Hong,Muratore, Michael,Bullion, Ann,Lin, Guoliang,Li, Huijie,Davis, Roderick,Lin, Xichen,Lakdawala, Ami S.,Cousins, Rick,Field, Rita,Payne, Jeremy,Miller, David D.,Bamborough, Paul,Christopher, John A.,Baldwin, Ian,Osborn, Ruth R.,Yonchuk, John,Webb, Edward,Rumsey, William L.

, p. 1164 - 1169 (2018/11/23)

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

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Page/Page column 189, (2008/12/04)

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

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